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- W2174654204 abstract "A combination of interferon-β (IFN-β) and all-trans retinoic acid (IFN/RA) induces tumor cell apoptosis via some unknown mechanisms. Apoptosis is a gene-directed process that limits the proliferation of undesired cells. Several genes are required to regulate cell death in the higher-order animals. Earlier, we employed a gene expression knockout technique to isolate cell death-related genes. A novel gene, the gene associated with retinoid-interferon-induced mortality-19 (GRIM-19), was found to be essential for tumor cell death induced by IFN/RA. Here, we describe the development and characterization of three monoclonal antibodies (mAbs) against GRIM-19. GRIM-19 is present in the nucleus and cytoplasm. Its expression is induced by the IFN/RA combination. We also show that GRIM-19 inhibits the cell-transforming property of viral oncogenic protein viral IFN regulatory factor-1 (vIRF-1) via a physical interaction. mAbs developed in this study should be useful for studying the other physiologic roles of GRIM-19 and serve as a potent tool for studying tumor responses to IFN/RA therapy." @default.
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- W2174654204 date "2002-10-01" @default.
- W2174654204 modified "2023-09-25" @default.
- W2174654204 title "Characterization of Monoclonal Antibodies Against GRIM-19, a Novel IFN-<i>β</i>and Retinoic Acid-Activated Regulator of Cell Death" @default.
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- W2174654204 doi "https://doi.org/10.1089/107999002760624242" @default.
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