FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2174659623> ?p ?o ?g. }

• W2174659623 endingPage "e0137904" @default.
• W2174659623 startingPage "e0137904" @default.
• W2174659623 abstract "Background The cardiovascular safety of inhaled long-acting β2-agonists (LABAs) in patients with chronic obstructive pulmonary disease (COPD) is a controversial problem. Certain studies have suggested that inhaled LABAs lead to an increased risk of cardiovascular events in patients with COPD. This meta-analysis aimed to assess the cardiovascular safety of inhaled LABAs in COPD. Methods A meta-analysis of randomized, double-blind, parallel-group, placebo-controlled trials for LABA treatment of COPD with at least 3 months of follow-up was performed. The fixed-effects model was used to evaluate the effects of LABAs on fatal cardiovascular adverse events. Adverse events were collected for each trial, and the relative risk (RR) and 95% confidence intervals (CI) for LABA/placebo were estimated. Results There were 24 trials included in this meta-analysis. Compared with placebo, inhaled LABAs significantly decreased fatal cardiovascular adverse events in COPD patients (RR 0.65, 95% CI 0.50 to 0.86, P = 0.002). In sensitivity analysis, there was still no increased risk of fatal cardiovascular events (RR 0.68, 95%CI 0.46 to 1.01, P = 0.06) after excluding the trial with the largest weight. Among the different types of LABAs, only salmeterol had a significant effect (RR 0.64, 95% CI 0.46 to 0.90). In subgroup analyses, inhaled LABAs were able to significantly decrease fatal cardiovascular events in long-term trials (RR 0.64, 95% CI 0.47 to 0.87) and in trials with severe COPD patients (RR 0.69, 95% CI 0.50 to 0.96). Conclusion Inhaled LABAs do not increase the risk of fatal cardiovascular events in COPD patients." @default.
• W2174659623 created "2016-06-24" @default.
• W2174659623 creator A5020559342 @default.
• W2174659623 creator A5030575955 @default.
• W2174659623 creator A5090316229 @default.
• W2174659623 date "2015-09-17" @default.
• W2174659623 modified "2023-10-04" @default.
• W2174659623 title "Inhaled Long-Acting β2-Agonists Do Not Increase Fatal Cardiovascular Adverse Events in COPD: A Meta-Analysis" @default.
• W2174659623 cites W1480729244 @default.
• W2174659623 cites W1495576818 @default.
• W2174659623 cites W178144282 @default.
• W2174659623 cites W1952594708 @default.
• W2174659623 cites W1972285749 @default.
• W2174659623 cites W1981197711 @default.
• W2174659623 cites W1986215651 @default.
• W2174659623 cites W1990601323 @default.
• W2174659623 cites W1990674750 @default.
• W2174659623 cites W1997443963 @default.
• W2174659623 cites W2004780292 @default.
• W2174659623 cites W2006528231 @default.
• W2174659623 cites W2008212067 @default.
• W2174659623 cites W2014032502 @default.
• W2174659623 cites W2016274438 @default.
• W2174659623 cites W2023554430 @default.
• W2174659623 cites W2032171019 @default.
• W2174659623 cites W2037238910 @default.
• W2174659623 cites W2038693293 @default.
• W2174659623 cites W2038697731 @default.
• W2174659623 cites W2039237831 @default.
• W2174659623 cites W2050533031 @default.
• W2174659623 cites W2053463673 @default.
• W2174659623 cites W2056040906 @default.
• W2174659623 cites W2058580481 @default.
• W2174659623 cites W2060873423 @default.
• W2174659623 cites W2072038990 @default.
• W2174659623 cites W2079777289 @default.
• W2174659623 cites W2086183206 @default.
• W2174659623 cites W2086872426 @default.
• W2174659623 cites W2088477168 @default.
• W2174659623 cites W2089834473 @default.
• W2174659623 cites W2094354458 @default.
• W2174659623 cites W2100907993 @default.
• W2174659623 cites W2106066604 @default.
• W2174659623 cites W2107345178 @default.
• W2174659623 cites W2108476086 @default.
• W2174659623 cites W2110783271 @default.
• W2174659623 cites W2113026917 @default.
• W2174659623 cites W2117079401 @default.
• W2174659623 cites W2119166127 @default.
• W2174659623 cites W2120629366 @default.
• W2174659623 cites W2123477530 @default.
• W2174659623 cites W2125435699 @default.
• W2174659623 cites W2125779455 @default.
• W2174659623 cites W2127539985 @default.
• W2174659623 cites W2129633626 @default.
• W2174659623 cites W2130703359 @default.
• W2174659623 cites W2130795051 @default.
• W2174659623 cites W2134122420 @default.
• W2174659623 cites W2134398120 @default.
• W2174659623 cites W2136569231 @default.
• W2174659623 cites W2141559845 @default.
• W2174659623 cites W2142430815 @default.
• W2174659623 cites W2142449488 @default.
• W2174659623 cites W2142724633 @default.
• W2174659623 cites W2144373581 @default.
• W2174659623 cites W2149495528 @default.
• W2174659623 cites W2163247562 @default.
• W2174659623 cites W4239080780 @default.
• W2174659623 doi "https://doi.org/10.1371/journal.pone.0137904" @default.
• W2174659623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4574772" @default.
• W2174659623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26378450" @default.
• W2174659623 hasPublicationYear "2015" @default.
• W2174659623 type Work @default.
• W2174659623 sameAs 2174659623 @default.
• W2174659623 citedByCount "20" @default.
• W2174659623 countsByYear W21746596232017 @default.
• W2174659623 countsByYear W21746596232018 @default.
• W2174659623 countsByYear W21746596232019 @default.
• W2174659623 countsByYear W21746596232020 @default.
• W2174659623 countsByYear W21746596232022 @default.
• W2174659623 countsByYear W21746596232023 @default.
• W2174659623 crossrefType "journal-article" @default.
• W2174659623 hasAuthorship W2174659623A5020559342 @default.
• W2174659623 hasAuthorship W2174659623A5030575955 @default.
• W2174659623 hasAuthorship W2174659623A5090316229 @default.
• W2174659623 hasBestOaLocation W21746596231 @default.
• W2174659623 hasConcept C126322002 @default.
• W2174659623 hasConcept C142724271 @default.
• W2174659623 hasConcept C168563851 @default.
• W2174659623 hasConcept C197934379 @default.
• W2174659623 hasConcept C204787440 @default.
• W2174659623 hasConcept C27081682 @default.
• W2174659623 hasConcept C2776719499 @default.
• W2174659623 hasConcept C2776780178 @default.
• W2174659623 hasConcept C42219234 @default.
• W2174659623 hasConcept C44249647 @default.
• W2174659623 hasConcept C71924100 @default.
• W2174659623 hasConcept C82789193 @default.

• next