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- W2174668049 abstract "GISTs are the most common mesenchymal tumors of the gastrointestinal tract, and the introduction of TKIs has revolutionized the management paradigm. Although most GISTs are symptomatic, a significant percentage is found incidentally, and hence a high degree of suspicion should be kept in mind when examining patients. For suspected mesenchymal tumors of the gastrointestinal tract, an immunohistochemical assay for KIT (CD117) should be performed. For primary, localized, and resectable GISTs, surgery continues to be the first-line treatment of choice. Imatinib mesylate has proven to be a dramatic and valuable discovery for the management of unresectable, recurrent, and metastatic GISTs, and more recently, sunitinib malate has shown promising results in the treatment of imatinib-resistant GISTs. Although currently not recommended, mutational analyses for risk-profile stratification will quite likely become standards of care in the near future. Data from ongoing trials evaluating adjuvant and neoadjuvant imatinib are expected to add more value to the current multidisciplinary approach for the optimal management of GISTs." @default.
- W2174668049 created "2016-06-24" @default.
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- W2174668049 date "2008-09-01" @default.
- W2174668049 modified "2023-09-25" @default.
- W2174668049 title "A case and literature review of complicated gastrointestinal stromal tumors." @default.
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