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• W2174697928 startingPage "763" @default.
• W2174697928 abstract "HIV-1 infection starts with fusion of the viral and the host cell membranes, a process mediated by the HIV-1 envelope glycoprotein trimer. The number of trimers required to complete membrane fusion, referred to as HIV-1 entry stoichiometry, remains under debate. A precise definition of HIV-1 entry stoichiometry is important as it reflects the efficacy of the viral entry process and steers the infectivity of HIV-1 virion populations. Initial estimates suggested a unanimous entry stoichiometry across HIV-1 strains while recent findings showed that HIV-1 strains can differ in entry stoichiometry. Here, we review current analyses of HIV-1 entry stoichiometry and point out future research directions to further define the interplay between entry stoichiometry, virus entry fitness, transmission, and susceptibility to antibody neutralization." @default.
• W2174697928 created "2016-06-24" @default.
• W2174697928 creator A5009994638 @default.
• W2174697928 creator A5011618392 @default.
• W2174697928 creator A5030209388 @default.
• W2174697928 creator A5061095609 @default.
• W2174697928 date "2015-12-01" @default.
• W2174697928 modified "2023-10-11" @default.
• W2174697928 title "The HIV-1 Entry Process: A Stoichiometric View" @default.
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