Matches in SemOpenAlex for { <https://semopenalex.org/work/W2174823906> ?p ?o ?g. }
- W2174823906 endingPage "2246" @default.
- W2174823906 startingPage "2231" @default.
- W2174823906 abstract "The metabolic properties of lymphomas derived from germinal center (GC) B cells have important implications for therapeutic strategies. In this study, we have compared metabolic features of Hodgkin-Reed-Sternberg (HRS) cells, the tumor cells of classical Hodgkin's lymphoma (cHL), one of the most frequent (post-)GC-derived B-cell lymphomas, with their normal GC B cell counterparts. We found that the ratio of oxidative to nonoxidative energy conversion was clearly shifted toward oxidative phosphorylation (OXPHOS)-linked ATP synthesis in HRS cells as compared to GC B cells. Mitochondrial mass, the expression of numerous key proteins of oxidative metabolism and markers of mitochondrial biogenesis were markedly upregulated in cHL cell lines and in primary cHL cases. NFkappaB promoted this shift to OXPHOS. Functional analysis indicated that both cell growth and viability of HRS cells depended on OXPHOS. The high rates of OXPHOS correlated with an almost complete lack of lactate production in HRS cells not observed in other GC B-cell lymphoma cell lines. Overall, we conclude that OXPHOS dominates energy conversion in HRS cells, while nonoxidative ATP production plays a subordinate role. Our results suggest that OXPHOS could be a new therapeutic target and may provide an avenue toward new treatment strategies in cHL." @default.
- W2174823906 created "2016-06-24" @default.
- W2174823906 creator A5006765832 @default.
- W2174823906 creator A5007005948 @default.
- W2174823906 creator A5008201869 @default.
- W2174823906 creator A5011402602 @default.
- W2174823906 creator A5018156469 @default.
- W2174823906 creator A5039845139 @default.
- W2174823906 creator A5045351514 @default.
- W2174823906 creator A5045853899 @default.
- W2174823906 creator A5058468216 @default.
- W2174823906 creator A5061378179 @default.
- W2174823906 creator A5068858945 @default.
- W2174823906 date "2016-01-18" @default.
- W2174823906 modified "2023-10-14" @default.
- W2174823906 title "Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation" @default.
- W2174823906 cites W1580867012 @default.
- W2174823906 cites W1630171124 @default.
- W2174823906 cites W1758280303 @default.
- W2174823906 cites W1972725743 @default.
- W2174823906 cites W1974567967 @default.
- W2174823906 cites W1982637127 @default.
- W2174823906 cites W1985011732 @default.
- W2174823906 cites W1987695736 @default.
- W2174823906 cites W1987885263 @default.
- W2174823906 cites W1990505770 @default.
- W2174823906 cites W1998166655 @default.
- W2174823906 cites W2019683289 @default.
- W2174823906 cites W2026198465 @default.
- W2174823906 cites W2028897202 @default.
- W2174823906 cites W2032102892 @default.
- W2174823906 cites W2036659083 @default.
- W2174823906 cites W2051181260 @default.
- W2174823906 cites W2051249711 @default.
- W2174823906 cites W2052543023 @default.
- W2174823906 cites W2055677253 @default.
- W2174823906 cites W2067174344 @default.
- W2174823906 cites W2069466069 @default.
- W2174823906 cites W2083929635 @default.
- W2174823906 cites W2086306477 @default.
- W2174823906 cites W2087301946 @default.
- W2174823906 cites W2094694817 @default.
- W2174823906 cites W2098267640 @default.
- W2174823906 cites W2105665764 @default.
- W2174823906 cites W2110467543 @default.
- W2174823906 cites W2117140251 @default.
- W2174823906 cites W2124673407 @default.
- W2174823906 cites W2125408763 @default.
- W2174823906 cites W2134956533 @default.
- W2174823906 cites W2137286147 @default.
- W2174823906 cites W2140225849 @default.
- W2174823906 cites W2147031820 @default.
- W2174823906 cites W2150382709 @default.
- W2174823906 cites W2151980465 @default.
- W2174823906 cites W2153850374 @default.
- W2174823906 cites W2154021280 @default.
- W2174823906 cites W2154663577 @default.
- W2174823906 cites W2156145814 @default.
- W2174823906 cites W2156877461 @default.
- W2174823906 cites W2159919133 @default.
- W2174823906 cites W2161128788 @default.
- W2174823906 cites W2171217650 @default.
- W2174823906 cites W324183564 @default.
- W2174823906 doi "https://doi.org/10.1002/ijc.29934" @default.
- W2174823906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26595876" @default.
- W2174823906 hasPublicationYear "2016" @default.
- W2174823906 type Work @default.
- W2174823906 sameAs 2174823906 @default.
- W2174823906 citedByCount "36" @default.
- W2174823906 countsByYear W21748239062016 @default.
- W2174823906 countsByYear W21748239062018 @default.
- W2174823906 countsByYear W21748239062019 @default.
- W2174823906 countsByYear W21748239062020 @default.
- W2174823906 countsByYear W21748239062021 @default.
- W2174823906 countsByYear W21748239062022 @default.
- W2174823906 countsByYear W21748239062023 @default.
- W2174823906 crossrefType "journal-article" @default.
- W2174823906 hasAuthorship W2174823906A5006765832 @default.
- W2174823906 hasAuthorship W2174823906A5007005948 @default.
- W2174823906 hasAuthorship W2174823906A5008201869 @default.
- W2174823906 hasAuthorship W2174823906A5011402602 @default.
- W2174823906 hasAuthorship W2174823906A5018156469 @default.
- W2174823906 hasAuthorship W2174823906A5039845139 @default.
- W2174823906 hasAuthorship W2174823906A5045351514 @default.
- W2174823906 hasAuthorship W2174823906A5045853899 @default.
- W2174823906 hasAuthorship W2174823906A5058468216 @default.
- W2174823906 hasAuthorship W2174823906A5061378179 @default.
- W2174823906 hasAuthorship W2174823906A5068858945 @default.
- W2174823906 hasBestOaLocation W21748239061 @default.
- W2174823906 hasConcept C159654299 @default.
- W2174823906 hasConcept C185592680 @default.
- W2174823906 hasConcept C203014093 @default.
- W2174823906 hasConcept C2777229759 @default.
- W2174823906 hasConcept C2778453870 @default.
- W2174823906 hasConcept C2779338263 @default.
- W2174823906 hasConcept C2779390272 @default.
- W2174823906 hasConcept C28859421 @default.
- W2174823906 hasConcept C2992779791 @default.