FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2174873488> ?p ?o ?g. }

• W2174873488 endingPage "139" @default.
• W2174873488 startingPage "131" @default.
• W2174873488 abstract "The present study aimed to investigate whether genetic polymorphisms in the Toll-like receptor (TLR)-4 and Toll/interleukin-1 receptor (TIR)-associated protein (TIRAP) genes, and/or their expression levels, influence the susceptibility of a patient to sepsis. A total of 106 patients with sepsis were divided into two groups on the basis of their acute physiology and chronic health evaluation (APACHE) II scores: i) Sepsis group A (APACHE II <20) and ii) Sepsis group B (APACHE II >20). In addition, 100 healthy volunteers were enrolled into the control group. Polymerase chain reaction-restriction fragment length polymorphism assay was used to detect the following genetic polymorphisms: The Ser180Leu allele of the TIRAP gene and the Asp299Gly and Thr399I1e alleles of the TLR4 gene. Furthermore, the protein expression levels of TLR4 and TIRAP were analyzed using an enzyme-linked immunosorbent assay. Genetic polymorphisms were not detected for the TLR4 and TIRAP genes; however, the protein expression levels of TLR4 and TIRAP differed significantly between the control, sepsis A and sepsis B groups (P<0.01). An APACHE II score of 20 was used as a baseline in order to differentiate sepsis severity. Pearson analysis demonstrated that TLR4 and TIRAP protein expression levels were positively correlated with sepsis severity (r=0.931 and 0.972; P<0.05), and TLR4 protein expression levels were positively correlated with those of TIRAP (r=0.936; P<0.05). The results of the present study suggested that the protein expression levels of, but not genetic polymorphisms in, TLR4 and TIRAP were associated with the severity of sepsis." @default.
• W2174873488 created "2016-06-24" @default.
• W2174873488 creator A5003889190 @default.
• W2174873488 creator A5012272710 @default.
• W2174873488 creator A5020495649 @default.
• W2174873488 creator A5034394855 @default.
• W2174873488 creator A5038766727 @default.
• W2174873488 creator A5040449489 @default.
• W2174873488 creator A5045773186 @default.
• W2174873488 creator A5051788465 @default.
• W2174873488 date "2015-11-19" @default.
• W2174873488 modified "2023-10-17" @default.
• W2174873488 title "The influence of genetic polymorphisms in TLR4 and TIRAP, and their expression levels in peripheral blood, on susceptibility to sepsis" @default.
• W2174873488 cites W1520365933 @default.
• W2174873488 cites W1600560134 @default.
• W2174873488 cites W1655860314 @default.
• W2174873488 cites W1815878669 @default.
• W2174873488 cites W1968144559 @default.
• W2174873488 cites W1969437137 @default.
• W2174873488 cites W1972835435 @default.
• W2174873488 cites W1973449422 @default.
• W2174873488 cites W1975840650 @default.
• W2174873488 cites W2009527638 @default.
• W2174873488 cites W2017736108 @default.
• W2174873488 cites W2035454589 @default.
• W2174873488 cites W2038486513 @default.
• W2174873488 cites W2046115820 @default.
• W2174873488 cites W2047754133 @default.
• W2174873488 cites W2049927822 @default.
• W2174873488 cites W2051769972 @default.
• W2174873488 cites W2069801714 @default.
• W2174873488 cites W2077152602 @default.
• W2174873488 cites W2078737011 @default.
• W2174873488 cites W2083178837 @default.
• W2174873488 cites W2087203965 @default.
• W2174873488 cites W2092954246 @default.
• W2174873488 cites W2104756748 @default.
• W2174873488 cites W2105919893 @default.
• W2174873488 cites W2106398910 @default.
• W2174873488 cites W2120239035 @default.
• W2174873488 cites W2133449490 @default.
• W2174873488 cites W2133804988 @default.
• W2174873488 cites W2136082432 @default.
• W2174873488 cites W2144136875 @default.
• W2174873488 cites W2156512948 @default.
• W2174873488 cites W2160243792 @default.
• W2174873488 cites W2165750136 @default.
• W2174873488 cites W2171144560 @default.
• W2174873488 cites W2177248394 @default.
• W2174873488 cites W2332505018 @default.
• W2174873488 cites W2407405722 @default.
• W2174873488 cites W3036294205 @default.
• W2174873488 doi "https://doi.org/10.3892/etm.2015.2884" @default.
• W2174873488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4726872" @default.
• W2174873488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26889229" @default.
• W2174873488 hasPublicationYear "2015" @default.
• W2174873488 type Work @default.
• W2174873488 sameAs 2174873488 @default.
• W2174873488 citedByCount "11" @default.
• W2174873488 countsByYear W21748734882016 @default.
• W2174873488 countsByYear W21748734882018 @default.
• W2174873488 countsByYear W21748734882019 @default.
• W2174873488 countsByYear W21748734882020 @default.
• W2174873488 countsByYear W21748734882022 @default.
• W2174873488 crossrefType "journal-article" @default.
• W2174873488 hasAuthorship W2174873488A5003889190 @default.
• W2174873488 hasAuthorship W2174873488A5012272710 @default.
• W2174873488 hasAuthorship W2174873488A5020495649 @default.
• W2174873488 hasAuthorship W2174873488A5034394855 @default.
• W2174873488 hasAuthorship W2174873488A5038766727 @default.
• W2174873488 hasAuthorship W2174873488A5040449489 @default.
• W2174873488 hasAuthorship W2174873488A5045773186 @default.
• W2174873488 hasAuthorship W2174873488A5051788465 @default.
• W2174873488 hasBestOaLocation W21748734881 @default.
• W2174873488 hasConcept C104317684 @default.
• W2174873488 hasConcept C180754005 @default.
• W2174873488 hasConcept C203014093 @default.
• W2174873488 hasConcept C2776070231 @default.
• W2174873488 hasConcept C2776914184 @default.
• W2174873488 hasConcept C2778384902 @default.
• W2174873488 hasConcept C49105822 @default.
• W2174873488 hasConcept C54355233 @default.
• W2174873488 hasConcept C71924100 @default.
• W2174873488 hasConcept C86803240 @default.
• W2174873488 hasConceptScore W2174873488C104317684 @default.
• W2174873488 hasConceptScore W2174873488C180754005 @default.
• W2174873488 hasConceptScore W2174873488C203014093 @default.
• W2174873488 hasConceptScore W2174873488C2776070231 @default.
• W2174873488 hasConceptScore W2174873488C2776914184 @default.
• W2174873488 hasConceptScore W2174873488C2778384902 @default.
• W2174873488 hasConceptScore W2174873488C49105822 @default.
• W2174873488 hasConceptScore W2174873488C54355233 @default.
• W2174873488 hasConceptScore W2174873488C71924100 @default.
• W2174873488 hasConceptScore W2174873488C86803240 @default.
• W2174873488 hasIssue "1" @default.
• W2174873488 hasLocation W21748734881 @default.
• W2174873488 hasLocation W21748734882 @default.
• W2174873488 hasLocation W21748734883 @default.

• next