FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2175039963> ?p ?o ?g. }

• W2175039963 endingPage "1233" @default.
• W2175039963 startingPage "1225" @default.
• W2175039963 abstract "Development of oral disintegrating tablets requires enhancement of drug dissolution and selection of sweetener. Co-crystallization of drugs with inert co-former is an emerging technique for enhancing dissolution rate. The benefit of this technique will become even greater if one of the sweeteners can act as co-crystal co-former to enhance dissolution and mask the taste. Accordingly, the objective of this work was to investigate the efficacy of sucralose as a potential co-crystal co-former for enhancing the dissolution rate of hydrochlorothiazide. This was extended to prepare oral disintegrating tablets. Co-crystallization was achieved after dissolving hydrochlorothiazide with increasing molar ratios of sucralose in the least amount of acetone. The co-crystallization products were characterized using Fourier transform infrared spectroscopy, differential thermal analysis and powder X-ray diffraction. These measurements indicated that co-crystallization process started at a drug sucralose molar ratio of 1:1 and completed at 1:2. The developed co-crystals exhibited faster drug dissolution compared with the control, with co-crystal containing the drug with sucralose at 1:2 molar ratio being optimum. The later was used to prepare fast disintegrating tablets. These tablets had acceptable physical characteristics and showed fast disintegration with subsequent rapid dissolution. The study introduced sucralose as co-crystal co-former for enhanced dissolution and masking the taste." @default.
• W2175039963 created "2016-06-24" @default.
• W2175039963 creator A5006977903 @default.
• W2175039963 creator A5062209787 @default.
• W2175039963 creator A5067740293 @default.
• W2175039963 creator A5087362532 @default.
• W2175039963 date "2015-12-07" @default.
• W2175039963 modified "2023-10-02" @default.
• W2175039963 title "Sucralose as co-crystal co-former for hydrochlorothiazide: development of oral disintegrating tablets" @default.
• W2175039963 cites W1808591434 @default.
• W2175039963 cites W1905674946 @default.
• W2175039963 cites W1988983428 @default.
• W2175039963 cites W1990329196 @default.
• W2175039963 cites W1990909186 @default.
• W2175039963 cites W1995423704 @default.
• W2175039963 cites W2005574399 @default.
• W2175039963 cites W2006226699 @default.
• W2175039963 cites W2018538448 @default.
• W2175039963 cites W2024944745 @default.
• W2175039963 cites W2033811533 @default.
• W2175039963 cites W2045228507 @default.
• W2175039963 cites W2065172707 @default.
• W2175039963 cites W2068232721 @default.
• W2175039963 cites W2076591465 @default.
• W2175039963 cites W2082351247 @default.
• W2175039963 cites W2098222684 @default.
• W2175039963 cites W2137446494 @default.
• W2175039963 cites W2143408925 @default.
• W2175039963 cites W2146886080 @default.
• W2175039963 cites W2151114776 @default.
• W2175039963 cites W2166401821 @default.
• W2175039963 cites W2314228231 @default.
• W2175039963 doi "https://doi.org/10.3109/03639045.2015.1118495" @default.
• W2175039963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26555927" @default.
• W2175039963 hasPublicationYear "2015" @default.
• W2175039963 type Work @default.
• W2175039963 sameAs 2175039963 @default.
• W2175039963 citedByCount "34" @default.
• W2175039963 countsByYear W21750399632016 @default.
• W2175039963 countsByYear W21750399632017 @default.
• W2175039963 countsByYear W21750399632018 @default.
• W2175039963 countsByYear W21750399632019 @default.
• W2175039963 countsByYear W21750399632020 @default.
• W2175039963 countsByYear W21750399632021 @default.
• W2175039963 countsByYear W21750399632022 @default.
• W2175039963 countsByYear W21750399632023 @default.
• W2175039963 crossrefType "journal-article" @default.
• W2175039963 hasAuthorship W2175039963A5006977903 @default.
• W2175039963 hasAuthorship W2175039963A5062209787 @default.
• W2175039963 hasAuthorship W2175039963A5067740293 @default.
• W2175039963 hasAuthorship W2175039963A5087362532 @default.
• W2175039963 hasConcept C126838900 @default.
• W2175039963 hasConcept C127413603 @default.
• W2175039963 hasConcept C13965031 @default.
• W2175039963 hasConcept C160892712 @default.
• W2175039963 hasConcept C178790620 @default.
• W2175039963 hasConcept C185592680 @default.
• W2175039963 hasConcept C192562407 @default.
• W2175039963 hasConcept C203036418 @default.
• W2175039963 hasConcept C2776480571 @default.
• W2175039963 hasConcept C2780361556 @default.
• W2175039963 hasConcept C31903555 @default.
• W2175039963 hasConcept C42360764 @default.
• W2175039963 hasConcept C43617362 @default.
• W2175039963 hasConcept C71924100 @default.
• W2175039963 hasConcept C84393581 @default.
• W2175039963 hasConcept C88380143 @default.
• W2175039963 hasConceptScore W2175039963C126838900 @default.
• W2175039963 hasConceptScore W2175039963C127413603 @default.
• W2175039963 hasConceptScore W2175039963C13965031 @default.
• W2175039963 hasConceptScore W2175039963C160892712 @default.
• W2175039963 hasConceptScore W2175039963C178790620 @default.
• W2175039963 hasConceptScore W2175039963C185592680 @default.
• W2175039963 hasConceptScore W2175039963C192562407 @default.
• W2175039963 hasConceptScore W2175039963C203036418 @default.
• W2175039963 hasConceptScore W2175039963C2776480571 @default.
• W2175039963 hasConceptScore W2175039963C2780361556 @default.
• W2175039963 hasConceptScore W2175039963C31903555 @default.
• W2175039963 hasConceptScore W2175039963C42360764 @default.
• W2175039963 hasConceptScore W2175039963C43617362 @default.
• W2175039963 hasConceptScore W2175039963C71924100 @default.
• W2175039963 hasConceptScore W2175039963C84393581 @default.
• W2175039963 hasConceptScore W2175039963C88380143 @default.
• W2175039963 hasIssue "8" @default.
• W2175039963 hasLocation W21750399631 @default.
• W2175039963 hasLocation W21750399632 @default.
• W2175039963 hasOpenAccess W2175039963 @default.
• W2175039963 hasPrimaryLocation W21750399631 @default.
• W2175039963 hasRelatedWork W1568831748 @default.
• W2175039963 hasRelatedWork W1964085724 @default.
• W2175039963 hasRelatedWork W2089227384 @default.
• W2175039963 hasRelatedWork W2169796533 @default.
• W2175039963 hasRelatedWork W2175039963 @default.
• W2175039963 hasRelatedWork W2349914492 @default.
• W2175039963 hasRelatedWork W2358619933 @default.
• W2175039963 hasRelatedWork W2366665319 @default.
• W2175039963 hasRelatedWork W2748952813 @default.
• W2175039963 hasRelatedWork W2899084033 @default.

• next