FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2175079504> ?p ?o ?g. }

• W2175079504 endingPage "1560" @default.
• W2175079504 startingPage "1551" @default.
• W2175079504 abstract "Severe deficiency of alpha-1 antitrypsin has a highly variable clinical presentation. The Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis α1 Study is a prospective, multicenter, cross-sectional study of adults older than age 35 years with PiZZ or PiMZ alpha-1 antitrypsin genotypes. It is designed to better understand if microbial factors influence this heterogeneity. Clinical symptoms, pulmonary function testing, computed chest tomography, exercise capacity, and bronchoalveolar lavage (BAL) will be used to define chronic obstructive pulmonary disease (COPD) phenotypes that can be studied with an integrated systems biology approach that includes plasma proteomics; mouth, BAL, and stool microbiome and virome analysis; and blood microRNA and blood mononuclear cell RNA and DNA profiling. We will rely on global genome, transcriptome, proteome, and metabolome datasets. Matched cohorts of PiZZ participants on or off alpha-1 antitrypsin augmentation therapy, PiMZ participants not on augmentation therapy, and control participants from the Subpopulations and Intermediate Outcome Measures in COPD Study who match on FEV1 and age will be compared. In the primary analysis, we will determine if the PiZZ individuals on augmentation therapy have a difference in lower respiratory tract microbes identified compared with matched PiZZ individuals who are not on augmentation therapy. By characterizing the microbiome in alpha-1 antitrypsin deficiency (AATD), we hope to define new phenotypes of COPD that explain some of the diversity of clinical presentations. As a unique genetic cause of COPD, AATD may inform typical COPD pathogenesis, and better understanding of it may illuminate the complex interplay between environment and genetics. Although the biologic approaches are hypothesis generating, the results may lead to development of novel biomarkers, better understanding of COPD phenotypes, and development of novel diagnostic and therapeutic trials in AATD and COPD. Clinical trial registered with www.clinicaltrials.gov (NCT01832220)." @default.
• W2175079504 created "2016-06-24" @default.
• W2175079504 creator A5006886866 @default.
• W2175079504 creator A5013378758 @default.
• W2175079504 creator A5015027977 @default.
• W2175079504 creator A5017665414 @default.
• W2175079504 creator A5028492706 @default.
• W2175079504 creator A5042031961 @default.
• W2175079504 creator A5056611075 @default.
• W2175079504 creator A5057800275 @default.
• W2175079504 creator A5062088708 @default.
• W2175079504 creator A5065866225 @default.
• W2175079504 creator A5072778023 @default.
• W2175079504 creator A5076389214 @default.
• W2175079504 creator A5082929960 @default.
• W2175079504 creator A5088823841 @default.
• W2175079504 date "2015-10-01" @default.
• W2175079504 modified "2023-09-27" @default.
• W2175079504 title "Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol" @default.
• W2175079504 cites W1617427609 @default.
• W2175079504 cites W1844134285 @default.
• W2175079504 cites W1877616531 @default.
• W2175079504 cites W1965753097 @default.
• W2175079504 cites W1965772763 @default.
• W2175079504 cites W1974846245 @default.
• W2175079504 cites W1976705029 @default.
• W2175079504 cites W1993347912 @default.
• W2175079504 cites W1997686025 @default.
• W2175079504 cites W2001625922 @default.
• W2175079504 cites W2002793477 @default.
• W2175079504 cites W2003025043 @default.
• W2175079504 cites W2006001174 @default.
• W2175079504 cites W2015373555 @default.
• W2175079504 cites W2024182441 @default.
• W2175079504 cites W2024682051 @default.
• W2175079504 cites W2028663641 @default.
• W2175079504 cites W2031033693 @default.
• W2175079504 cites W2033829453 @default.
• W2175079504 cites W2035643252 @default.
• W2175079504 cites W2038327024 @default.
• W2175079504 cites W2041732281 @default.
• W2175079504 cites W2047545735 @default.
• W2175079504 cites W2052124869 @default.
• W2175079504 cites W2053614631 @default.
• W2175079504 cites W2055906007 @default.
• W2175079504 cites W2058443388 @default.
• W2175079504 cites W2060950603 @default.
• W2175079504 cites W2062428707 @default.
• W2175079504 cites W2063718155 @default.
• W2175079504 cites W2064985248 @default.
• W2175079504 cites W2071338523 @default.
• W2175079504 cites W2078297752 @default.
• W2175079504 cites W2081169091 @default.
• W2175079504 cites W2082156775 @default.
• W2175079504 cites W2083120544 @default.
• W2175079504 cites W2085911000 @default.
• W2175079504 cites W2087018289 @default.
• W2175079504 cites W2095619968 @default.
• W2175079504 cites W2096445205 @default.
• W2175079504 cites W2097264524 @default.
• W2175079504 cites W2099430328 @default.
• W2175079504 cites W2100372559 @default.
• W2175079504 cites W2104081530 @default.
• W2175079504 cites W2105216609 @default.
• W2175079504 cites W2110342877 @default.
• W2175079504 cites W2120397327 @default.
• W2175079504 cites W2122573938 @default.
• W2175079504 cites W2126721550 @default.
• W2175079504 cites W2128806515 @default.
• W2175079504 cites W2131065421 @default.
• W2175079504 cites W2132122933 @default.
• W2175079504 cites W2135677683 @default.
• W2175079504 cites W2139582968 @default.
• W2175079504 cites W2141980700 @default.
• W2175079504 cites W2142772965 @default.
• W2175079504 cites W2142800258 @default.
• W2175079504 cites W2145466675 @default.
• W2175079504 cites W2153125626 @default.
• W2175079504 cites W2158831842 @default.
• W2175079504 cites W2159497758 @default.
• W2175079504 cites W2161251845 @default.
• W2175079504 cites W2161807399 @default.
• W2175079504 cites W2162602081 @default.
• W2175079504 doi "https://doi.org/10.1513/annalsats.201503-143oc" @default.
• W2175079504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4627425" @default.
• W2175079504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26153726" @default.
• W2175079504 hasPublicationYear "2015" @default.
• W2175079504 type Work @default.
• W2175079504 sameAs 2175079504 @default.
• W2175079504 citedByCount "10" @default.
• W2175079504 countsByYear W21750795042015 @default.
• W2175079504 countsByYear W21750795042017 @default.
• W2175079504 countsByYear W21750795042019 @default.
• W2175079504 countsByYear W21750795042020 @default.
• W2175079504 countsByYear W21750795042021 @default.
• W2175079504 countsByYear W21750795042022 @default.
• W2175079504 countsByYear W21750795042023 @default.
• W2175079504 crossrefType "journal-article" @default.

• next