Matches in SemOpenAlex for { <https://semopenalex.org/work/W2175133074> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2175133074 endingPage "4" @default.
- W2175133074 startingPage "220" @default.
- W2175133074 abstract "Neuropathic bone pain (NBP) due to bone metastases is estimated to affect about 15-25% of cancer patients experiencing pain. Numerous randomized trials have shown that single or multiple fraction radiotherapy (RT) for painful bone metastases produces intention-to-treat overall response rates (RRs) of approximately 60%, but there are few data on RT for NBP, per se. One randomized trial, Trans Tasman Radiation Oncology Group (TROG) 96.05 showed similar outcomes for NBP, although a single 8 Gy fraction was not proven to be as effective as fractionated treatment (20 Gy in five fractions), with RRs of 53% and 61%, respectively. A recent small, single institution series reported a comparable overall RR for NBP using a variety of fractionation schedules. Although TROG 96.05 found no statistically significant difference in the rates of re-treatment, spinal cord compression, or pathological fracture at the index site by arm, one subsequent single institution retrospective review cautioned against using single fractions for spine (the skeletal site causing the vast majority of NBP), particularly in the presence of high spinal instability scores. In that study, single fractions were associated with more spinal adverse events (including symptomatic vertebral compression fracture and spinal cord compression) than fractionated schedules. Although re-irradiation of bone metastases is feasible and moderately effective, there are no outcome data specific to re-treatment of NBP. In summary, NBP may appropriately be treated with fractionated RT, although single fractions may also be reasonable for patients with poor performance status and/or limited expected survival, and in centers with prolonged waiting times for fractionated treatment, given that re-treatment is possible for either. In addition, multiple fractions may be preferable for vertebral metastases in the setting of high spinal instability risk." @default.
- W2175133074 created "2016-06-24" @default.
- W2175133074 creator A5022076063 @default.
- W2175133074 date "2015-10-01" @default.
- W2175133074 modified "2023-09-26" @default.
- W2175133074 title "Radiotherapy for neuropathic pain due to bone metastases." @default.
- W2175133074 cites W1485593894 @default.
- W2175133074 cites W1823971301 @default.
- W2175133074 cites W2000309903 @default.
- W2175133074 cites W2023987851 @default.
- W2175133074 cites W2044072306 @default.
- W2175133074 cites W2053787128 @default.
- W2175133074 cites W2084514147 @default.
- W2175133074 cites W2089060860 @default.
- W2175133074 cites W2101137399 @default.
- W2175133074 cites W2117615545 @default.
- W2175133074 cites W2138156952 @default.
- W2175133074 cites W2164513741 @default.
- W2175133074 cites W3041284877 @default.
- W2175133074 doi "https://doi.org/10.3978/j.issn.2224-5820.2015.08.03" @default.
- W2175133074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26541402" @default.
- W2175133074 hasPublicationYear "2015" @default.
- W2175133074 type Work @default.
- W2175133074 sameAs 2175133074 @default.
- W2175133074 citedByCount "2" @default.
- W2175133074 countsByYear W21751330742015 @default.
- W2175133074 countsByYear W21751330742018 @default.
- W2175133074 crossrefType "journal-article" @default.
- W2175133074 hasAuthorship W2175133074A5022076063 @default.
- W2175133074 hasConcept C118552586 @default.
- W2175133074 hasConcept C141071460 @default.
- W2175133074 hasConcept C155806632 @default.
- W2175133074 hasConcept C168563851 @default.
- W2175133074 hasConcept C2777107010 @default.
- W2175133074 hasConcept C2778231337 @default.
- W2175133074 hasConcept C2779386548 @default.
- W2175133074 hasConcept C2780775167 @default.
- W2175133074 hasConcept C2993730151 @default.
- W2175133074 hasConcept C42219234 @default.
- W2175133074 hasConcept C509974204 @default.
- W2175133074 hasConcept C71924100 @default.
- W2175133074 hasConceptScore W2175133074C118552586 @default.
- W2175133074 hasConceptScore W2175133074C141071460 @default.
- W2175133074 hasConceptScore W2175133074C155806632 @default.
- W2175133074 hasConceptScore W2175133074C168563851 @default.
- W2175133074 hasConceptScore W2175133074C2777107010 @default.
- W2175133074 hasConceptScore W2175133074C2778231337 @default.
- W2175133074 hasConceptScore W2175133074C2779386548 @default.
- W2175133074 hasConceptScore W2175133074C2780775167 @default.
- W2175133074 hasConceptScore W2175133074C2993730151 @default.
- W2175133074 hasConceptScore W2175133074C42219234 @default.
- W2175133074 hasConceptScore W2175133074C509974204 @default.
- W2175133074 hasConceptScore W2175133074C71924100 @default.
- W2175133074 hasIssue "4" @default.
- W2175133074 hasLocation W21751330741 @default.
- W2175133074 hasOpenAccess W2175133074 @default.
- W2175133074 hasPrimaryLocation W21751330741 @default.
- W2175133074 hasRelatedWork W2044564816 @default.
- W2175133074 hasRelatedWork W2073238638 @default.
- W2175133074 hasRelatedWork W2170848359 @default.
- W2175133074 hasRelatedWork W2175133074 @default.
- W2175133074 hasRelatedWork W2280288173 @default.
- W2175133074 hasRelatedWork W2348857921 @default.
- W2175133074 hasRelatedWork W2355233588 @default.
- W2175133074 hasRelatedWork W2981349706 @default.
- W2175133074 hasRelatedWork W2982306021 @default.
- W2175133074 hasRelatedWork W3210705565 @default.
- W2175133074 hasVolume "4" @default.
- W2175133074 isParatext "false" @default.
- W2175133074 isRetracted "false" @default.
- W2175133074 magId "2175133074" @default.
- W2175133074 workType "article" @default.