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- W2175225119 abstract "In the course of screening for anti-dementia agents from natural products, a beta-secretase (BACE1) inhibitor was isolated from the culture broth of Phellinus linteus and identified as hispidin. It showed an IC (50) value of 4.9 x 10 (-6) M and a Ki value of 8.4 x 10 (-6) M. The compound was a non-competitive inhibitor. Hispidin also inhibited a prolyl endopeptidase (IC (50) = 1.6 x 10 (-5) M, Ki = 2.4 x 10 (-5) M), but it was less inhibitory to alpha-secretase (TACE) and other serine proteases such as chymotrypsin, trypsin, and elastase." @default.
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- W2175225119 date "2004-02-01" @default.
- W2175225119 modified "2023-10-18" @default.
- W2175225119 title "A β-Secretase (BACE1) Inhibitor Hispidin from the Mycelial Cultures of<i>Phellinus linteus</i>" @default.
- W2175225119 doi "https://doi.org/10.1055/s-2004-815491" @default.
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