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• W2175360818 abstract "This study aims to assess the clinical utility of a rapid fiber-optic Raman spectroscopy technique developed for enhancing<italic>in vivo</italic>diagnosis of gastric precancer during endoscopic examination. We have developed a real-time fiber-optic Raman spectroscopy system capable of simultaneously acquiring both fingerprint (FP) (<italic>i.e.</italic>, 800–1800 cm⁻¹) and high-wavenumber (HW) (<italic>i.e.</italic>, 2800–3600 cm⁻¹) Raman spectra from gastric tissue<italic>in vivo</italic>at endoscopy. A total of 5792 high-quality<italic>in vivo</italic>FP/HW Raman spectra (normal (<italic>n</italic>= 5160); dysplasia (<italic>n</italic>= 155), and adenocarcinoma (<italic>n</italic>= 477)) were acquired in real-time from 441 tissue sites (normal (<italic>n</italic>= 396); dysplasia (<italic>n</italic>= 11), and adenocarcinoma (<italic>n</italic>= 34)) of 191 gastric patients (normal (<italic>n</italic>= 172); dysplasia (<italic>n</italic>= 6), and adenocarcinoma (<italic>n</italic>= 13)) undergoing routine endoscopic examinations. Partial least squares discriminant analysis (PLS-DA) together with leave-one-patient-out cross validation (LOPCV) were implemented to develop robust spectral diagnostic models. The FP/HW Raman spectra differ significantly between normal, dysplasia and adenocarcinoma of the stomach, which can be attributed to changes in proteins, lipids, nucleic acids, and the bound water content. PLS-DA and LOPCV show that the fiber-optic FP/HW Raman spectroscopy provides diagnostic sensitivities of 96.0%, 81.8% and 88.2%, and specificities of 86.7%, 95.3% and 95.6%, respectively, for the classification of normal, dysplastic and cancerous gastric tissue, superior to either the FP or HW Raman techniques alone. Further dichotomous PLS-DA analysis yields a sensitivity of 90.9% (10/11) and specificity of 95.9% (380/396) for the detection of gastric dysplasia using FP/HW Raman spectroscopy, substantiating its clinical advantages over white light reflectance endoscopy (sensitivity: 90.9% (10/11), and specificity: 51.0% (202/396)). This work demonstrates that the fiber-optic FP/HW Raman spectroscopy technique has great promise for enhancing<italic>in vivo</italic>diagnosis of gastric precancer during routine endoscopic examination." @default.
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• W2175360818 date "2016-01-01" @default.
• W2175360818 modified "2023-10-14" @default.
• W2175360818 title "Fiber-optic Raman spectroscopy for in vivo diagnosis of gastric dysplasia" @default.
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• W2175360818 doi "https://doi.org/10.1039/c5fd00151j" @default.
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