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• W2175444047 abstract "A common feature of the brain is the arrangement of synapses in layers. To examine the significance of this organizational feature, we studied the functional development of direction-selective (DS) circuits in the tectum of astray mutant zebrafish in which lamination of retinal ganglion cell (RGC) axons is lost. We show that although never laminar, the tuning of DS-RGC axons targeting the mutant tectum is normal. Analysis of mutant tectal neurons at late developmental stages reveals that directional tuning is indistinguishable from wild-type larvae. Furthermore, we show that structural plasticity of tectal dendrites and RGC axons compensates for the loss of lamination, establishing connectivity between DS-RGCs and their normal tectal targets. However, tectal direction selectivity is severely perturbed at earlier developmental stages. Thus, the formation of synaptic laminae is ultimately dispensable for the correct wiring of direction-selective tectal circuits, but it is crucial for the rapid assembly of these networks.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiJkYjlhOTA0MmUzYTYxMWVhYzcyODUyNTlhYjlhYjIyMiIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4Mjk2NDg2fQ.eHrSinLiiBDcPofKGnG3tJWuhlRkN2hBVp6y2eY8QHrDLamyZutpmb68VWa6W55YGLGrQXpEApte5auboA6ZVCsoRKOTsnIHk7i8cylr9ZE7-7E_sLfXQdsZe6e_6rRJ6HPvL_MzEB31VPstuSt70jBRFTW33_dyDA9cF_dU9aarAIQecUdaiO7jqiEICDLZdzqNS9AtyRR9ZUyvdZPyJoOuJP1HaIpm-OwF6qnIBdzjjaiWAUBdtwEwPdij3Dke7L9Jg5EU068njXCSSbAynMTyUIrA9VVP0bB88dnYZ5sYtpaht7hHD6MLR1BPhKOGJJXMgtC_bew0bWobJWZuEQ(mp4, (23.7 MB) Download video" @default.
• W2175444047 created "2016-06-24" @default.
• W2175444047 creator A5015767534 @default.
• W2175444047 creator A5083719621 @default.
• W2175444047 date "2015-12-01" @default.
• W2175444047 modified "2023-10-03" @default.
• W2175444047 title "Lamination Speeds the Functional Development of Visual Circuits" @default.
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• W2175444047 doi "https://doi.org/10.1016/j.neuron.2015.10.020" @default.
• W2175444047 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4674658" @default.
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