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- W2175472525 abstract "Despite the availability of over 20 antiepileptic drugs (AEDs), many patients continue to live with uncontrolled seizures and the consequences of refractory epilepsy and its treatment. This chapter reviews several potential AEDs in early clinical development. These agents are summarized in terms of their chemistry, activity in animal models and mechanism of action, pharmacokinetics, drug interactions, efficacy and adverse effects. The chapter reviews the pharmacology, pharmacokinetics, drug interaction, efficacy and adverse effect profiles of several investigational AEDs currently in development. These are allopregnanolone (SAGE-547 Injection), cannabinoids, 2-Deoxy-d-glucose, everolimus, ganaxolone, and huperzine A (INS-001). Reviews of NAX 810-2, pitolisant, PRX-00023 (naluzotan), selurampanel, tonabersat, and YKP3089 are also presented. Genomic research is uncovering the molecular underpinnings of a number of specific epilepsy syndromes, and associated conditions, such as intellectual disability and autism. Molecular genetic aetiologies of epilepsy will pave the path for novel therapeutic opportunities to treat patients according to genotype." @default.
- W2175472525 created "2016-06-24" @default.
- W2175472525 creator A5033042596 @default.
- W2175472525 creator A5088706930 @default.
- W2175472525 date "2015-10-02" @default.
- W2175472525 modified "2023-09-27" @default.
- W2175472525 title "Drugs in Clinical Development" @default.
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- W2175472525 doi "https://doi.org/10.1002/9781118936979.ch55" @default.
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