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• W2175487732 abstract "Mesoamerican nephropathy (MeN), an epidemic in Central America, is a chronic kidney disease of unknown cause. In this article, we argue that MeN may be a uric acid disorder. Individuals at risk for developing the disease are primarily male workers exposed to heat stress and physical exertion that predisposes to recurrent water and volume depletion, often accompanied by urinary concentration and acidification. Uric acid is generated during heat stress, in part consequent to nucleotide release from muscles. We hypothesize that working in the sugarcane fields may result in cyclic uricosuria in which uric acid concentrations exceed solubility, leading to the formation of dihydrate urate crystals and local injury. Consistent with this hypothesis, we present pilot data documenting the common presence of urate crystals in the urine of sugarcane workers from El Salvador. High end-of-workday urinary uric acid concentrations were common in a pilot study, particularly if urine pH was corrected to 7. Hyperuricemia may induce glomerular hypertension, whereas the increased urinary uric acid may directly injure renal tubules. Thus, MeN may result from exercise and heat stress associated with dehydration-induced hyperuricemia and uricosuria. Increased hydration with water and salt, urinary alkalinization, reduction in sugary beverage intake, and inhibitors of uric acid synthesis should be tested for disease prevention." @default.
• W2175487732 created "2016-06-24" @default.
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• W2175487732 date "2016-01-01" @default.
• W2175487732 modified "2023-10-18" @default.
• W2175487732 title "Heat Stress Nephropathy From Exercise-Induced Uric Acid Crystalluria: A Perspective on Mesoamerican Nephropathy" @default.
• W2175487732 cites W1019814866 @default.
• W2175487732 cites W110991517 @default.
• W2175487732 cites W146664859 @default.
• W2175487732 cites W1546245101 @default.
• W2175487732 cites W1912444978 @default.
• W2175487732 cites W1964198430 @default.
• W2175487732 cites W1965720496 @default.
• W2175487732 cites W1972725839 @default.
• W2175487732 cites W1982192233 @default.
• W2175487732 cites W1985355228 @default.
• W2175487732 cites W1985484058 @default.
• W2175487732 cites W1985489594 @default.
• W2175487732 cites W1990460736 @default.
• W2175487732 cites W1990544066 @default.
• W2175487732 cites W1999556806 @default.
• W2175487732 cites W2000292809 @default.
• W2175487732 cites W2000365724 @default.
• W2175487732 cites W2002567714 @default.
• W2175487732 cites W2004120221 @default.
• W2175487732 cites W2005980936 @default.
• W2175487732 cites W2007313000 @default.
• W2175487732 cites W2008851837 @default.
• W2175487732 cites W2009617989 @default.
• W2175487732 cites W2013120400 @default.
• W2175487732 cites W2016690683 @default.
• W2175487732 cites W2018384359 @default.
• W2175487732 cites W2018588185 @default.
• W2175487732 cites W2020473773 @default.
• W2175487732 cites W2022597200 @default.
• W2175487732 cites W2030788558 @default.
• W2175487732 cites W2033982773 @default.
• W2175487732 cites W2034707276 @default.
• W2175487732 cites W2034863097 @default.
• W2175487732 cites W2039312335 @default.
• W2175487732 cites W2045516356 @default.
• W2175487732 cites W2048170654 @default.
• W2175487732 cites W2048779286 @default.
• W2175487732 cites W2053473295 @default.
• W2175487732 cites W2054907175 @default.
• W2175487732 cites W2055270042 @default.
• W2175487732 cites W2056197193 @default.
• W2175487732 cites W2062813383 @default.
• W2175487732 cites W2063007022 @default.
• W2175487732 cites W2063161169 @default.
• W2175487732 cites W2064249981 @default.
• W2175487732 cites W2065486513 @default.
• W2175487732 cites W2070928249 @default.
• W2175487732 cites W2077474379 @default.
• W2175487732 cites W2077820136 @default.
• W2175487732 cites W2091101255 @default.
• W2175487732 cites W2092788099 @default.
• W2175487732 cites W2093635964 @default.
• W2175487732 cites W2097767113 @default.
• W2175487732 cites W2104009398 @default.
• W2175487732 cites W2104681259 @default.
• W2175487732 cites W2105150333 @default.
• W2175487732 cites W2106202735 @default.
• W2175487732 cites W2106269091 @default.
• W2175487732 cites W2106403351 @default.
• W2175487732 cites W2107946601 @default.
• W2175487732 cites W2109489366 @default.
• W2175487732 cites W2120390687 @default.
• W2175487732 cites W2120793874 @default.
• W2175487732 cites W2122983268 @default.
• W2175487732 cites W2125784583 @default.
• W2175487732 cites W2125942122 @default.
• W2175487732 cites W2129291585 @default.
• W2175487732 cites W2129493921 @default.
• W2175487732 cites W2129967807 @default.
• W2175487732 cites W2130757125 @default.
• W2175487732 cites W2131658070 @default.
• W2175487732 cites W2133709762 @default.
• W2175487732 cites W2136298697 @default.
• W2175487732 cites W2137951385 @default.
• W2175487732 cites W2140075992 @default.
• W2175487732 cites W2144878621 @default.
• W2175487732 cites W2145724683 @default.
• W2175487732 cites W2146024715 @default.
• W2175487732 cites W2146809897 @default.

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