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- W2175496795 abstract "C-4 Fluorination of a series of 3,5-diarylisoxazoles has been accomplished using the N-F reagent Selectfluor®. With substrates containing neutral or activating substituents on the 5-phenyl ring, acetonitrile at room temperature or at reflux could be used as solvent. However, when deactivating substituents were present, a higher reaction temperature was required for which sulfolane was found to be a good solvent. At this higher temperature, a unique trifluorination of the isoxazole nucleus by an addition mechanism occurred as a side reaction." @default.
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- W2175496795 date "2004-12-01" @default.
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- W2175496795 title "Nuclear fluorination of 3,5-diarylisoxazoles with Selectfluor®" @default.
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- W2175496795 doi "https://doi.org/10.1016/j.jfluchem.2004.08.001" @default.
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