FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2175514210> ?p ?o ?g. }

• W2175514210 endingPage "1010" @default.
• W2175514210 startingPage "999" @default.
• W2175514210 abstract "Protein translation typically begins with the recruitment of the 43S ribosomal complex to the 5′ cap of mRNAs by a cap-binding complex. However, some transcripts are translated in a cap-independent manner through poorly understood mechanisms. Here, we show that mRNAs containing N6-methyladenosine (m6A) in their 5′ UTR can be translated in a cap-independent manner. A single 5′ UTR m6A directly binds eukaryotic initiation factor 3 (eIF3), which is sufficient to recruit the 43S complex to initiate translation in the absence of the cap-binding factor eIF4E. Inhibition of adenosine methylation selectively reduces translation of mRNAs containing 5′UTR m6A. Additionally, increased m6A levels in the Hsp70 mRNA regulate its cap-independent translation following heat shock. Notably, we find that diverse cellular stresses induce a transcriptome-wide redistribution of m6A, resulting in increased numbers of mRNAs with 5′ UTR m6A. These data show that 5′ UTR m6A bypasses 5′ cap-binding proteins to promote translation under stresses." @default.
• W2175514210 created "2016-06-24" @default.
• W2175514210 creator A5023241832 @default.
• W2175514210 creator A5030719973 @default.
• W2175514210 creator A5046085522 @default.
• W2175514210 creator A5051743981 @default.
• W2175514210 creator A5053334268 @default.
• W2175514210 creator A5061702711 @default.
• W2175514210 creator A5067570812 @default.
• W2175514210 creator A5078045401 @default.
• W2175514210 creator A5080848884 @default.
• W2175514210 date "2015-11-01" @default.
• W2175514210 modified "2023-10-17" @default.
• W2175514210 title "5′ UTR m6A Promotes Cap-Independent Translation" @default.
• W2175514210 cites W1941339056 @default.
• W2175514210 cites W1964015026 @default.
• W2175514210 cites W1965395430 @default.
• W2175514210 cites W1970949525 @default.
• W2175514210 cites W1977233304 @default.
• W2175514210 cites W1983273401 @default.
• W2175514210 cites W1991807334 @default.
• W2175514210 cites W2004526658 @default.
• W2175514210 cites W2008410413 @default.
• W2175514210 cites W2009308529 @default.
• W2175514210 cites W2043995661 @default.
• W2175514210 cites W2045773985 @default.
• W2175514210 cites W2064128480 @default.
• W2175514210 cites W2065305397 @default.
• W2175514210 cites W2065847836 @default.
• W2175514210 cites W2071930821 @default.
• W2175514210 cites W2072141763 @default.
• W2175514210 cites W2078964320 @default.
• W2175514210 cites W2079918544 @default.
• W2175514210 cites W2084459589 @default.
• W2175514210 cites W2102872651 @default.
• W2175514210 cites W2104493977 @default.
• W2175514210 cites W2109941922 @default.
• W2175514210 cites W2120296922 @default.
• W2175514210 cites W2137417707 @default.
• W2175514210 cites W2140491044 @default.
• W2175514210 cites W2157495054 @default.
• W2175514210 cites W2157497892 @default.
• W2175514210 cites W2162739904 @default.
• W2175514210 cites W2416130463 @default.
• W2175514210 cites W4248136323 @default.
• W2175514210 cites W776567260 @default.
• W2175514210 doi "https://doi.org/10.1016/j.cell.2015.10.012" @default.
• W2175514210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4695625" @default.
• W2175514210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26593424" @default.
• W2175514210 hasPublicationYear "2015" @default.
• W2175514210 type Work @default.
• W2175514210 sameAs 2175514210 @default.
• W2175514210 citedByCount "1293" @default.
• W2175514210 countsByYear W21755142102015 @default.
• W2175514210 countsByYear W21755142102016 @default.
• W2175514210 countsByYear W21755142102017 @default.
• W2175514210 countsByYear W21755142102018 @default.
• W2175514210 countsByYear W21755142102019 @default.
• W2175514210 countsByYear W21755142102020 @default.
• W2175514210 countsByYear W21755142102021 @default.
• W2175514210 countsByYear W21755142102022 @default.
• W2175514210 countsByYear W21755142102023 @default.
• W2175514210 crossrefType "journal-article" @default.
• W2175514210 hasAuthorship W2175514210A5023241832 @default.
• W2175514210 hasAuthorship W2175514210A5030719973 @default.
• W2175514210 hasAuthorship W2175514210A5046085522 @default.
• W2175514210 hasAuthorship W2175514210A5051743981 @default.
• W2175514210 hasAuthorship W2175514210A5053334268 @default.
• W2175514210 hasAuthorship W2175514210A5061702711 @default.
• W2175514210 hasAuthorship W2175514210A5067570812 @default.
• W2175514210 hasAuthorship W2175514210A5078045401 @default.
• W2175514210 hasAuthorship W2175514210A5080848884 @default.
• W2175514210 hasBestOaLocation W21755142101 @default.
• W2175514210 hasConcept C104317684 @default.
• W2175514210 hasConcept C105580179 @default.
• W2175514210 hasConcept C117838200 @default.
• W2175514210 hasConcept C12464233 @default.
• W2175514210 hasConcept C149364088 @default.
• W2175514210 hasConcept C161295673 @default.
• W2175514210 hasConcept C22667442 @default.
• W2175514210 hasConcept C33277056 @default.
• W2175514210 hasConcept C41282012 @default.
• W2175514210 hasConcept C4718897 @default.
• W2175514210 hasConcept C54355233 @default.
• W2175514210 hasConcept C62493599 @default.
• W2175514210 hasConcept C77430603 @default.
• W2175514210 hasConcept C86803240 @default.
• W2175514210 hasConcept C89604277 @default.
• W2175514210 hasConcept C95444343 @default.
• W2175514210 hasConcept C97154109 @default.
• W2175514210 hasConceptScore W2175514210C104317684 @default.
• W2175514210 hasConceptScore W2175514210C105580179 @default.
• W2175514210 hasConceptScore W2175514210C117838200 @default.
• W2175514210 hasConceptScore W2175514210C12464233 @default.
• W2175514210 hasConceptScore W2175514210C149364088 @default.
• W2175514210 hasConceptScore W2175514210C161295673 @default.
• W2175514210 hasConceptScore W2175514210C22667442 @default.
• W2175514210 hasConceptScore W2175514210C33277056 @default.

• next