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• W2175532272 endingPage "L635" @default.
• W2175532272 startingPage "L628" @default.
• W2175532272 abstract "Secreted protein acidic and rich in cysteine (SPARC) has been shown to be coexpressed with type I collagen in tissues undergoing remodeling and wound repair. We speculated that SPARC is required for the accumulation of collagen in lung injury and that its absence would attenuate collagen accumulation. Accordingly, we have assessed levels of collagen in SPARC-null mice in an intratracheal bleomycin-injury model of pulmonary fibrosis. Eight- to ten-week-old SPARC-null and wild-type (WT) mice received bleomycin (0.0035 U/g) or saline intratracheally and were subsequently killed after 14 days. Relative levels of SPARC mRNA were increased 2.7-fold (P < 0.001) in bleomycin-treated WT lungs in comparison with saline-treated lungs. Protein from bleomycin-treated WT lung contained significantly more hydroxyproline (191.9 microg/lung) than protein from either bleomycin-treated SPARC-null lungs or saline-treated WT and SPARC-null lungs (147.4 microg/lung, 125.4 microg/lung, and 113. 0 microg/lung, respectively; P < 0.03). These results indicate that SPARC is increased in response to lung injury and that accumulation of collagen, as indicated by hydroxyproline content, is attenuated in the absence of SPARC. The properties of SPARC as a matricellular protein associated with cell proliferation and matrix turnover are consistent with its participation in the development of pulmonary fibrosis." @default.
• W2175532272 created "2016-06-24" @default.
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• W2175532272 creator A5014192293 @default.
• W2175532272 creator A5037474143 @default.
• W2175532272 date "1999-09-01" @default.
• W2175532272 modified "2023-10-18" @default.
• W2175532272 title "Collagen accumulation is decreased in SPARC-null mice with bleomycin-induced pulmonary fibrosis" @default.
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• W2175532272 doi "https://doi.org/10.1152/ajplung.1999.277.3.l628" @default.
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