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- W2175606906 abstract "To describe chelation therapy with d-penicillamine for treatment of zinc toxicosis in a dog.A 1.5-year-old intact female Maltese dog weighing 2.7 kg was presented with acute, progressive anorexia, lethargy, pigmenturia, and melena. The owner reported that the dog had ingested a hook from a dog leash made of a zinc-based alloy 9 days prior. A blood transfusion was administered and an abdominal radiograph revealed a metal-dense foreign body in the stomach. Laboratory findings revealed a serum zinc concentration of 1845.12 μg/dL (reference interval, 70-200 μg/dL) and a decreased hematocrit that remained low despite removal of the zinc foreign body. On day 3, another blood transfusion was performed and d-penicillamine therapy was instituted. After the administration of d-penicillamine, the clinical signs and hemogram progressively improved and the dog was discharged 2 days later. On day 9 after initial presentation, the hematocrit and platelet values were within normal limits and the serum zinc concentration was 280.16 μg/dL.This case demonstrates the use of d-penicillamine in the treatment of zinc toxicosis. Serum zinc concentration appeared to decline more rapidly after administration of d-penicillamine than before chelation therapy. This is the first report to evaluate serial serum zinc concentrations before and during chelation therapy with d-penicillamine." @default.
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- W2175606906 date "2015-11-20" @default.
- W2175606906 modified "2023-10-14" @default.
- W2175606906 title "Treatment of zinc toxicosis in a dog with chelation using<scp>d</scp>-penicillamine" @default.
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- W2175606906 doi "https://doi.org/10.1111/vec.12414" @default.
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