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• W2175643223 abstract "[reaction: see text] Synthetic strategies for preparing N,N'-bridged oligomeric guanidines bearing peptide side chains both on solid support and in solution are presented. Monomers are prepared from common alpha-amino acids and therefore contain conventionally protected peptide side chains. The side chains include alkyl, aromatic, hydroxyl, amino, carboxylic acid, and amide functional groups. Oligomer elongation utilizes acid-sensitive sulfonyl activated thiourea through the formation of carbodiimide intermediate. With proper preparation of monomers, synthesis of oligomer can be performed in two directions (equivalent to N to C terminal or C to N terminal in a peptide sequence) with excellent efficiency." @default.
• W2175643223 created "2016-06-24" @default.
• W2175643223 creator A5002725172 @default.
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• W2175643223 date "2005-10-01" @default.
• W2175643223 modified "2023-10-03" @default.
• W2175643223 title "Solid-Phase and Solution-Phase Syntheses of Oligomeric Guanidines Bearing Peptide Side Chains" @default.
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• W2175643223 doi "https://doi.org/10.1021/jo051226t" @default.
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