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• W2175647908 abstract "This chapter discusses an approach for the development of an automated oligosaccharide synthesizer. To meet the demand for molecular tools, new methods for the rapid production of carbohydrates are needed. Carbohydrates are the most stereochemically challenging class of biopolymers to prepare, and different methods have been developed to address their synthesis. In addition to traditional solution-phase chemical synthesis, three methods—enzymatic methods, orthogonal one-pot chemical methods, and automated solid-phase methods—have become increasingly popular for the construction of oligosaccharides. The chapter develops an automated solid-phase approach for the chemical synthesis of oligosaccharides. In this study, by using an acceptor-bound solid-phase glycosylation strategy in a specially designed instrument, poly α- (1 → 2) mannosides as large as a decasaccharide were synthesized. The use of glycosyl phosphates was demonstrated with the synthesis of a dodecamer phytoalexin elicitor b-glucan. During this investigation, high-resolution magic angle-spinning nuclear magnetic resonance (HR-MAS NMR) analysis was used as an on-resin analytical tool. The method described in the chapter is anticipated to have a significant impact on the field of oligosaccharide synthesis. Although there are still a number of challenges to overcome, the automated construction of glycosidic linkages is expected to allow for the preparation of a diverse set of carbohydrate for pharmaceutical and biochemical evaluation." @default.
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• W2175647908 date "2003-01-01" @default.
• W2175647908 modified "2023-09-26" @default.
• W2175647908 title "DEVELOPMENT OF AN AUTOMATED OLIGOSACCHARIDE SYNTHESIZER" @default.
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• W2175647908 doi "https://doi.org/10.1016/s0065-2318(03)58002-7" @default.
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