Matches in SemOpenAlex for { <https://semopenalex.org/work/W2175657898> ?p ?o ?g. }
- W2175657898 endingPage "82" @default.
- W2175657898 startingPage "72" @default.
- W2175657898 abstract "Visfatin, a recently discovered adipocytokine, has been shown to have an important role in the pathogenesis of diabetic nephropathy (DN). The farnesoid X receptor (FXR), a ligand-activated nuclear receptor, plays a protective role in DN. The regulation between FXR and visfatin and their interaction in DN has not been well established. In this study, we reported that FXR agonist GW4064 reduced high glucose induced human mesangial cells (HMCs) inflammation, fibrosis and proliferation by downregulating visfatin expression, which can be blunted by exogenous visfatin treatment. Moreover, luciferase reporter assay showed FXR regulated visfatin transcription activity probably by binding to the -1607 bp and -1192 bp region of the visfatin promoter. In vivo study also showed that GW4064 ameliorated the progression of DN in db/db mice with a decreased visfatin expression. These findings suggest that FXR activation delayed the progression of diabetic nephropathy and this effect is through downregulating visfatin." @default.
- W2175657898 created "2016-06-24" @default.
- W2175657898 creator A5019038570 @default.
- W2175657898 creator A5025384599 @default.
- W2175657898 creator A5028082252 @default.
- W2175657898 creator A5044865265 @default.
- W2175657898 creator A5050093533 @default.
- W2175657898 creator A5061234914 @default.
- W2175657898 creator A5064123614 @default.
- W2175657898 creator A5071124887 @default.
- W2175657898 creator A5079983839 @default.
- W2175657898 creator A5089289098 @default.
- W2175657898 date "2016-01-01" @default.
- W2175657898 modified "2023-10-15" @default.
- W2175657898 title "Activation of farnesoid X receptor downregulates visfatin and attenuates diabetic nephropathy" @default.
- W2175657898 cites W1592519647 @default.
- W2175657898 cites W1963864987 @default.
- W2175657898 cites W1966922165 @default.
- W2175657898 cites W1968994034 @default.
- W2175657898 cites W1970363592 @default.
- W2175657898 cites W1970740746 @default.
- W2175657898 cites W1976621716 @default.
- W2175657898 cites W1995354538 @default.
- W2175657898 cites W1997664301 @default.
- W2175657898 cites W1997676435 @default.
- W2175657898 cites W1999917583 @default.
- W2175657898 cites W2004498697 @default.
- W2175657898 cites W2011020293 @default.
- W2175657898 cites W2015768468 @default.
- W2175657898 cites W2018677912 @default.
- W2175657898 cites W2030672139 @default.
- W2175657898 cites W2045223517 @default.
- W2175657898 cites W2045702834 @default.
- W2175657898 cites W2047711197 @default.
- W2175657898 cites W2052725031 @default.
- W2175657898 cites W2053407516 @default.
- W2175657898 cites W2063491068 @default.
- W2175657898 cites W2068458442 @default.
- W2175657898 cites W2072670533 @default.
- W2175657898 cites W2082583283 @default.
- W2175657898 cites W2094906530 @default.
- W2175657898 cites W2095747615 @default.
- W2175657898 cites W2102401087 @default.
- W2175657898 cites W2106678312 @default.
- W2175657898 cites W2108192985 @default.
- W2175657898 cites W2108810370 @default.
- W2175657898 cites W2111314858 @default.
- W2175657898 cites W2112644387 @default.
- W2175657898 cites W2122709204 @default.
- W2175657898 cites W2128878020 @default.
- W2175657898 cites W2142427646 @default.
- W2175657898 cites W2159639597 @default.
- W2175657898 cites W2162017875 @default.
- W2175657898 cites W2323160006 @default.
- W2175657898 cites W2098460778 @default.
- W2175657898 doi "https://doi.org/10.1016/j.mce.2015.10.001" @default.
- W2175657898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26450152" @default.
- W2175657898 hasPublicationYear "2016" @default.
- W2175657898 type Work @default.
- W2175657898 sameAs 2175657898 @default.
- W2175657898 citedByCount "12" @default.
- W2175657898 countsByYear W21756578982016 @default.
- W2175657898 countsByYear W21756578982017 @default.
- W2175657898 countsByYear W21756578982018 @default.
- W2175657898 countsByYear W21756578982019 @default.
- W2175657898 countsByYear W21756578982020 @default.
- W2175657898 countsByYear W21756578982022 @default.
- W2175657898 countsByYear W21756578982023 @default.
- W2175657898 crossrefType "journal-article" @default.
- W2175657898 hasAuthorship W2175657898A5019038570 @default.
- W2175657898 hasAuthorship W2175657898A5025384599 @default.
- W2175657898 hasAuthorship W2175657898A5028082252 @default.
- W2175657898 hasAuthorship W2175657898A5044865265 @default.
- W2175657898 hasAuthorship W2175657898A5050093533 @default.
- W2175657898 hasAuthorship W2175657898A5061234914 @default.
- W2175657898 hasAuthorship W2175657898A5064123614 @default.
- W2175657898 hasAuthorship W2175657898A5071124887 @default.
- W2175657898 hasAuthorship W2175657898A5079983839 @default.
- W2175657898 hasAuthorship W2175657898A5089289098 @default.
- W2175657898 hasConcept C104317684 @default.
- W2175657898 hasConcept C126322002 @default.
- W2175657898 hasConcept C127561419 @default.
- W2175657898 hasConcept C134018914 @default.
- W2175657898 hasConcept C170493617 @default.
- W2175657898 hasConcept C185592680 @default.
- W2175657898 hasConcept C203862802 @default.
- W2175657898 hasConcept C2776914184 @default.
- W2175657898 hasConcept C2778938600 @default.
- W2175657898 hasConcept C2779922275 @default.
- W2175657898 hasConcept C55493867 @default.
- W2175657898 hasConcept C555293320 @default.
- W2175657898 hasConcept C63932345 @default.
- W2175657898 hasConcept C71924100 @default.
- W2175657898 hasConcept C86339819 @default.
- W2175657898 hasConceptScore W2175657898C104317684 @default.
- W2175657898 hasConceptScore W2175657898C126322002 @default.
- W2175657898 hasConceptScore W2175657898C127561419 @default.
- W2175657898 hasConceptScore W2175657898C134018914 @default.