Matches in SemOpenAlex for { <https://semopenalex.org/work/W2175679446> ?p ?o ?g. }
- W2175679446 endingPage "302" @default.
- W2175679446 startingPage "285" @default.
- W2175679446 abstract "When viruses enter the host, they are first detected by the innate immune system, which comprises cytokines, sentinel cells (dendritic cells [DCs] and macrophages), complement, and natural killer (NK) cells. A second family of pattern recognition receptors comprises the cytoplasmic sensors of viral nucleic acids, MDA-5 (melanoma differentiation associated gene-5), RIG-I (retinoic acid-inducible gene I), and LGP2. Interferon (IFN) production after infection of cultured cells with paramyxoviruses, VSV, influenza virus, and the flavivirus Japanese encephalitis virus is impaired in fibroblasts from rig-I-1- mice. RIG- I- like receptors (RLRs) play central roles in viral recognition and induction of antiviral innate responses in cDCs, macrophages, and fibroblasts. Infection of mda-5-1- mice revealed that this protein is critical for detection of infection with picornaviruses, but not flaviviruses, influenza viruses, or paramyxoviruses. Mice lacking the nitric oxide synthase gene have reduced macrophage activation and β-cell apoptosis and consequently reduced virus-induced diabetes. Understanding viral countermeasures not only improves one's understanding of innate sensing pathways but may also suggest avenues for therapeutic intervention. Infection of cells with several picornaviruses leads to cleavage or degradation of MDA-5 and RIG-I. We survive only because we possess powerful intrinsic, innate, and adaptive immune defense systems. The study of how picornaviruses interact with the innate immune system is in its infancy. Understanding innate signaling pathways and how viruses counteract them should be a productive area of research for many years." @default.
- W2175679446 created "2016-06-24" @default.
- W2175679446 creator A5080318036 @default.
- W2175679446 date "2014-04-30" @default.
- W2175679446 modified "2023-09-25" @default.
- W2175679446 title "Innate Immune Responses" @default.
- W2175679446 cites W1500123828 @default.
- W2175679446 cites W1569857352 @default.
- W2175679446 cites W1571024301 @default.
- W2175679446 cites W1639028758 @default.
- W2175679446 cites W1798984988 @default.
- W2175679446 cites W1964642249 @default.
- W2175679446 cites W1966390603 @default.
- W2175679446 cites W1967896668 @default.
- W2175679446 cites W1968637854 @default.
- W2175679446 cites W1972977209 @default.
- W2175679446 cites W1978503782 @default.
- W2175679446 cites W1982839782 @default.
- W2175679446 cites W1986516584 @default.
- W2175679446 cites W1990815259 @default.
- W2175679446 cites W1997913859 @default.
- W2175679446 cites W1999556384 @default.
- W2175679446 cites W2000572318 @default.
- W2175679446 cites W2004312418 @default.
- W2175679446 cites W2005503891 @default.
- W2175679446 cites W2007608885 @default.
- W2175679446 cites W2009127910 @default.
- W2175679446 cites W2009708031 @default.
- W2175679446 cites W2010846919 @default.
- W2175679446 cites W2011678998 @default.
- W2175679446 cites W2013092102 @default.
- W2175679446 cites W2016194523 @default.
- W2175679446 cites W2016357017 @default.
- W2175679446 cites W2017515700 @default.
- W2175679446 cites W2018148368 @default.
- W2175679446 cites W2018828712 @default.
- W2175679446 cites W2019063202 @default.
- W2175679446 cites W2022443610 @default.
- W2175679446 cites W2025582367 @default.
- W2175679446 cites W2026266565 @default.
- W2175679446 cites W2027498268 @default.
- W2175679446 cites W2028575270 @default.
- W2175679446 cites W2028882640 @default.
- W2175679446 cites W2032539461 @default.
- W2175679446 cites W2032980461 @default.
- W2175679446 cites W2034172998 @default.
- W2175679446 cites W2040589516 @default.
- W2175679446 cites W2043887962 @default.
- W2175679446 cites W2046013214 @default.
- W2175679446 cites W2046691663 @default.
- W2175679446 cites W2049923099 @default.
- W2175679446 cites W2052932569 @default.
- W2175679446 cites W2057227767 @default.
- W2175679446 cites W2058022316 @default.
- W2175679446 cites W2059984502 @default.
- W2175679446 cites W2060323608 @default.
- W2175679446 cites W2062490839 @default.
- W2175679446 cites W2063145133 @default.
- W2175679446 cites W2064134024 @default.
- W2175679446 cites W2065220920 @default.
- W2175679446 cites W2065554630 @default.
- W2175679446 cites W2067685745 @default.
- W2175679446 cites W2068551986 @default.
- W2175679446 cites W2072325387 @default.
- W2175679446 cites W2078319759 @default.
- W2175679446 cites W2078539040 @default.
- W2175679446 cites W2079046408 @default.
- W2175679446 cites W2080336124 @default.
- W2175679446 cites W2082800992 @default.
- W2175679446 cites W2085394255 @default.
- W2175679446 cites W2085919832 @default.
- W2175679446 cites W2086958200 @default.
- W2175679446 cites W2087147878 @default.
- W2175679446 cites W2091978007 @default.
- W2175679446 cites W2092019188 @default.
- W2175679446 cites W2092498488 @default.
- W2175679446 cites W2093579074 @default.
- W2175679446 cites W2095353564 @default.
- W2175679446 cites W2096372976 @default.
- W2175679446 cites W2100041032 @default.
- W2175679446 cites W2100665873 @default.
- W2175679446 cites W2101083359 @default.
- W2175679446 cites W2101479766 @default.
- W2175679446 cites W2107513655 @default.
- W2175679446 cites W2111750260 @default.
- W2175679446 cites W2112359700 @default.
- W2175679446 cites W2113961792 @default.
- W2175679446 cites W2117963002 @default.
- W2175679446 cites W2118926211 @default.
- W2175679446 cites W2121203278 @default.
- W2175679446 cites W2124205618 @default.
- W2175679446 cites W2125566625 @default.
- W2175679446 cites W2125775699 @default.
- W2175679446 cites W2126205901 @default.
- W2175679446 cites W2127290428 @default.
- W2175679446 cites W2128847991 @default.
- W2175679446 cites W2131575325 @default.
- W2175679446 cites W2133006561 @default.