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• W2175804913 abstract "Abstract It has been reported that genes up-regulated in cancer are often down-regulated in neurodegenerative disorders and vice versa . The fact that apparently unrelated diseases share functional pathways suggests a link between their etiopathogenesis and the properties of molecules involved. Are there specific features that explain the exclusive association of proteins with either cancer or neurodegeneration? We performed a large-scale analysis of physico-chemical properties to understand what characteristics differentiate classes of diseases. We found that structural disorder significantly distinguishes proteins up-regulated in neurodegenerative diseases from those linked to cancer. We also observed high correlation between structural disorder and age of onset in Frontotemporal Dementia, Parkinson’s and Alzheimer’s diseases, which strongly supports the role of protein unfolding in neurodegenerative processes." @default.
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• W2175804913 date "2015-10-23" @default.
• W2175804913 modified "2023-10-14" @default.
• W2175804913 title "Neurodegeneration and Cancer: Where the Disorder Prevails" @default.
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• W2175804913 doi "https://doi.org/10.1038/srep15390" @default.
• W2175804913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4615981" @default.
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• W2175804913 hasPublicationYear "2015" @default.
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