Matches in SemOpenAlex for { <https://semopenalex.org/work/W2175927900> ?p ?o ?g. }
- W2175927900 endingPage "870" @default.
- W2175927900 startingPage "862" @default.
- W2175927900 abstract "A series of Fmoc-Phe(4-aza-C60)-OH of fullerene amino acid derived peptides have been prepared by solid phase peptide synthesis, in which the terminal amino acid, Phe(4-aza-C60)-OH, is derived from the dipolar addition to C60 of the Fmoc-Nα-protected azido amino acids derived from phenylalanine: Fmoc-Phe(4-aza-C60)-Lys3-OH (1), Fmoc-Phe(4-aza-C60)-Pro-Hyp-Lys-OH (2), and Fmoc-Phe(4-aza-C60)-Hyp-Hyp-Lys-OH (3). The inhibition constant of our fullerene aspartic protease PRIs utilized FRET-based assay to evaluate the enzyme kinetics of HIV-1 PR at various concentrations of inhibitors. Simulation of the docking of the peptide Fmoc-Phe-Pro-Hyp-Lys-OH overestimated the inhibition, while the amino acid PRIs were well estimated. The experimental results show that C60-based amino acids are a good base structure in the design of protease inhibitors and that their inhibition can be improved upon by the addition of designer peptide sequences. Copyright © 2015 European Peptide Society and John Wiley & Sons, Ltd." @default.
- W2175927900 created "2016-06-24" @default.
- W2175927900 creator A5035013697 @default.
- W2175927900 creator A5036246783 @default.
- W2175927900 creator A5052555333 @default.
- W2175927900 creator A5073841758 @default.
- W2175927900 creator A5080235407 @default.
- W2175927900 creator A5083419769 @default.
- W2175927900 date "2015-11-26" @default.
- W2175927900 modified "2023-09-30" @default.
- W2175927900 title "Fullerene-based inhibitors of HIV-1 protease" @default.
- W2175927900 cites W1965349185 @default.
- W2175927900 cites W1980075422 @default.
- W2175927900 cites W1981737096 @default.
- W2175927900 cites W1985651999 @default.
- W2175927900 cites W1993377322 @default.
- W2175927900 cites W1995396220 @default.
- W2175927900 cites W2004424330 @default.
- W2175927900 cites W2004573841 @default.
- W2175927900 cites W2005110339 @default.
- W2175927900 cites W2008588049 @default.
- W2175927900 cites W2010114197 @default.
- W2175927900 cites W2022152519 @default.
- W2175927900 cites W2022973223 @default.
- W2175927900 cites W2027918837 @default.
- W2175927900 cites W2030402747 @default.
- W2175927900 cites W2031168104 @default.
- W2175927900 cites W2035123832 @default.
- W2175927900 cites W2035711908 @default.
- W2175927900 cites W2045633646 @default.
- W2175927900 cites W2046346311 @default.
- W2175927900 cites W2059657647 @default.
- W2175927900 cites W2069506489 @default.
- W2175927900 cites W2070624290 @default.
- W2175927900 cites W2072332451 @default.
- W2175927900 cites W2074294128 @default.
- W2175927900 cites W2077670895 @default.
- W2175927900 cites W2080336516 @default.
- W2175927900 cites W2091379422 @default.
- W2175927900 cites W2100303014 @default.
- W2175927900 cites W2103342951 @default.
- W2175927900 cites W2104270610 @default.
- W2175927900 cites W2105175831 @default.
- W2175927900 cites W2106453589 @default.
- W2175927900 cites W2111017461 @default.
- W2175927900 cites W2133240807 @default.
- W2175927900 cites W2135986253 @default.
- W2175927900 cites W2169458804 @default.
- W2175927900 cites W2171316918 @default.
- W2175927900 cites W2174684160 @default.
- W2175927900 cites W2210033643 @default.
- W2175927900 cites W2949745155 @default.
- W2175927900 cites W4239840825 @default.
- W2175927900 doi "https://doi.org/10.1002/psc.2828" @default.
- W2175927900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26767741" @default.
- W2175927900 hasPublicationYear "2015" @default.
- W2175927900 type Work @default.
- W2175927900 sameAs 2175927900 @default.
- W2175927900 citedByCount "29" @default.
- W2175927900 countsByYear W21759279002016 @default.
- W2175927900 countsByYear W21759279002017 @default.
- W2175927900 countsByYear W21759279002018 @default.
- W2175927900 countsByYear W21759279002019 @default.
- W2175927900 countsByYear W21759279002020 @default.
- W2175927900 countsByYear W21759279002021 @default.
- W2175927900 countsByYear W21759279002022 @default.
- W2175927900 countsByYear W21759279002023 @default.
- W2175927900 crossrefType "journal-article" @default.
- W2175927900 hasAuthorship W2175927900A5035013697 @default.
- W2175927900 hasAuthorship W2175927900A5036246783 @default.
- W2175927900 hasAuthorship W2175927900A5052555333 @default.
- W2175927900 hasAuthorship W2175927900A5073841758 @default.
- W2175927900 hasAuthorship W2175927900A5080235407 @default.
- W2175927900 hasAuthorship W2175927900A5083419769 @default.
- W2175927900 hasConcept C159110408 @default.
- W2175927900 hasConcept C181199279 @default.
- W2175927900 hasConcept C185592680 @default.
- W2175927900 hasConcept C21951064 @default.
- W2175927900 hasConcept C2776714187 @default.
- W2175927900 hasConcept C2777431362 @default.
- W2175927900 hasConcept C2779281246 @default.
- W2175927900 hasConcept C41685203 @default.
- W2175927900 hasConcept C515207424 @default.
- W2175927900 hasConcept C55493867 @default.
- W2175927900 hasConcept C71240020 @default.
- W2175927900 hasConcept C71924100 @default.
- W2175927900 hasConceptScore W2175927900C159110408 @default.
- W2175927900 hasConceptScore W2175927900C181199279 @default.
- W2175927900 hasConceptScore W2175927900C185592680 @default.
- W2175927900 hasConceptScore W2175927900C21951064 @default.
- W2175927900 hasConceptScore W2175927900C2776714187 @default.
- W2175927900 hasConceptScore W2175927900C2777431362 @default.
- W2175927900 hasConceptScore W2175927900C2779281246 @default.
- W2175927900 hasConceptScore W2175927900C41685203 @default.
- W2175927900 hasConceptScore W2175927900C515207424 @default.
- W2175927900 hasConceptScore W2175927900C55493867 @default.
- W2175927900 hasConceptScore W2175927900C71240020 @default.
- W2175927900 hasConceptScore W2175927900C71924100 @default.