FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2176057246> ?p ?o ?g. }

• W2176057246 endingPage "2245" @default.
• W2176057246 startingPage "2234" @default.
• W2176057246 abstract "OprG is an outer membrane protein of Pseudomonas aeruginosa whose function as an antibiotic-sensitive porin has been controversial and not well defined. Circumstantial evidence led to the proposal that OprG might transport hydrophobic compounds by using a lateral gate in the barrel wall thought to be lined by three conserved prolines. To test this hypothesis and to find the physiological substrates of OprG, we reconstituted the purified protein into liposomes and found it to facilitate the transport of small amino acids such as glycine, alanine, valine, and serine, which was confirmed by Pseudomonas growth assays. The structures of wild-type and a critical proline mutant were determined by nuclear magnetic resonance in dihexanoyl-phosphatidylcholine micellar solutions. Both proteins formed eight-stranded β-barrels with flexible extracellular loops. The interfacial prolines did not form a lateral gate in these structures, but loop 3 exhibited restricted motions in the inactive P92A mutant but not in wild-type OprG." @default.
• W2176057246 created "2016-06-24" @default.
• W2176057246 creator A5011046074 @default.
• W2176057246 creator A5014889450 @default.
• W2176057246 creator A5020008848 @default.
• W2176057246 creator A5021277644 @default.
• W2176057246 creator A5032713306 @default.
• W2176057246 date "2015-12-01" @default.
• W2176057246 modified "2023-09-25" @default.
• W2176057246 title "OprG Harnesses the Dynamics of its Extracellular Loops to Transport Small Amino Acids across the Outer Membrane of Pseudomonas aeruginosa" @default.
• W2176057246 cites W1589295940 @default.
• W2176057246 cites W1751253656 @default.
• W2176057246 cites W1968585055 @default.
• W2176057246 cites W1970351230 @default.
• W2176057246 cites W1975459052 @default.
• W2176057246 cites W1981267913 @default.
• W2176057246 cites W1990112908 @default.
• W2176057246 cites W1990122271 @default.
• W2176057246 cites W1995017064 @default.
• W2176057246 cites W1995251464 @default.
• W2176057246 cites W1995411885 @default.
• W2176057246 cites W1998484367 @default.
• W2176057246 cites W2005988933 @default.
• W2176057246 cites W2012771513 @default.
• W2176057246 cites W2018410651 @default.
• W2176057246 cites W2021938691 @default.
• W2176057246 cites W2027299926 @default.
• W2176057246 cites W2030321217 @default.
• W2176057246 cites W2037108053 @default.
• W2176057246 cites W2042281432 @default.
• W2176057246 cites W2059953204 @default.
• W2176057246 cites W2062999231 @default.
• W2176057246 cites W2066900950 @default.
• W2176057246 cites W2074398530 @default.
• W2176057246 cites W2077679785 @default.
• W2176057246 cites W2079207558 @default.
• W2176057246 cites W2084902262 @default.
• W2176057246 cites W2091581640 @default.
• W2176057246 cites W2091741783 @default.
• W2176057246 cites W2104439851 @default.
• W2176057246 cites W2112418305 @default.
• W2176057246 cites W2119587675 @default.
• W2176057246 cites W2122334299 @default.
• W2176057246 cites W2128433990 @default.
• W2176057246 cites W2137434580 @default.
• W2176057246 cites W2139251535 @default.
• W2176057246 cites W2139669165 @default.
• W2176057246 cites W2145020089 @default.
• W2176057246 cites W2148993275 @default.
• W2176057246 cites W2155698468 @default.
• W2176057246 cites W2166025323 @default.
• W2176057246 cites W2321052603 @default.
• W2176057246 cites W2331160130 @default.
• W2176057246 cites W3169130203 @default.
• W2176057246 cites W84251742 @default.
• W2176057246 cites W97423149 @default.
• W2176057246 doi "https://doi.org/10.1016/j.str.2015.10.009" @default.
• W2176057246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4699568" @default.
• W2176057246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26655471" @default.
• W2176057246 hasPublicationYear "2015" @default.
• W2176057246 type Work @default.
• W2176057246 sameAs 2176057246 @default.
• W2176057246 citedByCount "26" @default.
• W2176057246 countsByYear W21760572462016 @default.
• W2176057246 countsByYear W21760572462017 @default.
• W2176057246 countsByYear W21760572462018 @default.
• W2176057246 countsByYear W21760572462020 @default.
• W2176057246 countsByYear W21760572462021 @default.
• W2176057246 crossrefType "journal-article" @default.
• W2176057246 hasAuthorship W2176057246A5011046074 @default.
• W2176057246 hasAuthorship W2176057246A5014889450 @default.
• W2176057246 hasAuthorship W2176057246A5020008848 @default.
• W2176057246 hasAuthorship W2176057246A5021277644 @default.
• W2176057246 hasAuthorship W2176057246A5032713306 @default.
• W2176057246 hasBestOaLocation W21760572461 @default.
• W2176057246 hasConcept C104317684 @default.
• W2176057246 hasConcept C12554922 @default.
• W2176057246 hasConcept C143065580 @default.
• W2176057246 hasConcept C146587185 @default.
• W2176057246 hasConcept C185592680 @default.
• W2176057246 hasConcept C2777317804 @default.
• W2176057246 hasConcept C2777637488 @default.
• W2176057246 hasConcept C2777756961 @default.
• W2176057246 hasConcept C2779815552 @default.
• W2176057246 hasConcept C2779856020 @default.
• W2176057246 hasConcept C28406088 @default.
• W2176057246 hasConcept C515207424 @default.
• W2176057246 hasConcept C523546767 @default.
• W2176057246 hasConcept C54355233 @default.
• W2176057246 hasConcept C547475151 @default.
• W2176057246 hasConcept C55493867 @default.
• W2176057246 hasConcept C86803240 @default.
• W2176057246 hasConceptScore W2176057246C104317684 @default.
• W2176057246 hasConceptScore W2176057246C12554922 @default.
• W2176057246 hasConceptScore W2176057246C143065580 @default.
• W2176057246 hasConceptScore W2176057246C146587185 @default.
• W2176057246 hasConceptScore W2176057246C185592680 @default.
• W2176057246 hasConceptScore W2176057246C2777317804 @default.

• next