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• W2176083926 abstract "A series of urea-based N-1-(2-aminoethyl)-indazoles was synthesized and evaluated for melanin-concentrating hormone receptor 1 (MCHr1) antagonism in both binding and functional assays. Several compounds that acted as MCHr1 antagonists were identified, and optimization afforded a compound with excellent binding affinity, good functional potency, and oral efficacy in a chronic model for weight loss in diet-induced obese mice." @default.
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• W2176083926 date "2005-06-01" @default.
• W2176083926 modified "2023-10-16" @default.
• W2176083926 title "Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity" @default.
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• W2176083926 doi "https://doi.org/10.1016/j.bmcl.2005.03.114" @default.
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