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- W2176112770 abstract "To secure their access to water, light, and nutrients, many plant species have developed allelopathic strategies to suppress competitors. To this end, they release into the rhizosphere phytotoxic substances that inhibit the germination and growth of neighbors. Despite the importance of allelopathy in shaping natural plant communities and for agricultural production, the underlying molecular mechanisms are largely unknown. Here, we report that allelochemicals derived from the common class of cyclic hydroxamic acid root exudates directly affect the chromatin-modifying machinery in Arabidopsis thaliana. These allelochemicals inhibit histone deacetylases both in vitro and in vivo and exert their activity through locus-specific alterations of histone acetylation and associated gene expression. Our multilevel analysis collectively shows how plant-plant interactions interfere with a fundamental cellular process, histone acetylation, by targeting an evolutionarily highly conserved class of enzymes." @default.
- W2176112770 created "2016-06-24" @default.
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- W2176112770 date "2015-11-01" @default.
- W2176112770 modified "2023-10-16" @default.
- W2176112770 title "Plants Release Precursors of Histone Deacetylase Inhibitors to Suppress Growth of Competitors" @default.
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- W2176112770 doi "https://doi.org/10.1105/tpc.15.00585" @default.
- W2176112770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4682303" @default.
- W2176112770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26530086" @default.
- W2176112770 hasPublicationYear "2015" @default.
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