Matches in SemOpenAlex for { <https://semopenalex.org/work/W2176144786> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2176144786 endingPage "1455" @default.
- W2176144786 startingPage "1451" @default.
- W2176144786 abstract "Objective:To investigate the effect of nicotine to HMGB-1 concentration and survival of sepsis rats.Method:The rats were executed cecal ligation and puncture for experimental sepsis which randomly divided into 5 groups(fake operation,blankcontrol,physiological saline,positive control and nicotine).The inflammation factors,such as TNF-α,IL-6 and HMGB-1 concentration were tested by ELSA.Compared these inflammation factors concentration in different group.To assess the survival rate of different groups by Kaplan-Meier method.After then,to assess nicotine effects on experimental sepsis rats at different dose-rates and in different administration time.Results:After cecal ligation and puncture,TNF-αand IL-6 concentration of all groups obviously increased at once,after two days the concentration to reach the peak,and then began to decline.Compared the uptrend,blank control and physiological saline group was obviously higher than other three groups(p0.05).The HMGB-1 concentration of all groups obviously increased after cecal ligation and puncture two days,the concentration to reach the peak after 5 days,and then began to decline.Compared the uptrend,fake operation and nicotine group obviously slower than other three groups(p0.05).The best concentration and administration time of nicotine to experimental sepsis rats was 200ug per kilogram of body weight and 24 hours after executed cecal ligation and puncture respectively.Compared the other four groups,nicotine significant decreased the HMGB-1 concentration of experimental sepsis rats.Compared the survival rate,the nicotine group was obviously higher than blank control and physiological saline group(p0.05).Conclusion:Nicotine can significant decreased the HMGB-1 concentration of experimental sepsis rats,also can improve the survival rate of experimental sepsis rats.Nicotine has a certain therapeutic action for experimental sepsis rats." @default.
- W2176144786 created "2016-06-24" @default.
- W2176144786 creator A5015333988 @default.
- W2176144786 creator A5016797934 @default.
- W2176144786 creator A5023057624 @default.
- W2176144786 creator A5040212661 @default.
- W2176144786 creator A5055029468 @default.
- W2176144786 creator A5062310021 @default.
- W2176144786 creator A5088891531 @default.
- W2176144786 date "2010-01-01" @default.
- W2176144786 modified "2023-09-26" @default.
- W2176144786 title "Influence of nicotine on survival rate of experimental sepsis rats." @default.
- W2176144786 hasPublicationYear "2010" @default.
- W2176144786 type Work @default.
- W2176144786 sameAs 2176144786 @default.
- W2176144786 citedByCount "0" @default.
- W2176144786 crossrefType "journal-article" @default.
- W2176144786 hasAuthorship W2176144786A5015333988 @default.
- W2176144786 hasAuthorship W2176144786A5016797934 @default.
- W2176144786 hasAuthorship W2176144786A5023057624 @default.
- W2176144786 hasAuthorship W2176144786A5040212661 @default.
- W2176144786 hasAuthorship W2176144786A5055029468 @default.
- W2176144786 hasAuthorship W2176144786A5062310021 @default.
- W2176144786 hasAuthorship W2176144786A5088891531 @default.
- W2176144786 hasConcept C126322002 @default.
- W2176144786 hasConcept C179437574 @default.
- W2176144786 hasConcept C2776283816 @default.
- W2176144786 hasConcept C2776914184 @default.
- W2176144786 hasConcept C2777397205 @default.
- W2176144786 hasConcept C2778384902 @default.
- W2176144786 hasConcept C2779547902 @default.
- W2176144786 hasConcept C42219234 @default.
- W2176144786 hasConcept C71924100 @default.
- W2176144786 hasConcept C98274493 @default.
- W2176144786 hasConceptScore W2176144786C126322002 @default.
- W2176144786 hasConceptScore W2176144786C179437574 @default.
- W2176144786 hasConceptScore W2176144786C2776283816 @default.
- W2176144786 hasConceptScore W2176144786C2776914184 @default.
- W2176144786 hasConceptScore W2176144786C2777397205 @default.
- W2176144786 hasConceptScore W2176144786C2778384902 @default.
- W2176144786 hasConceptScore W2176144786C2779547902 @default.
- W2176144786 hasConceptScore W2176144786C42219234 @default.
- W2176144786 hasConceptScore W2176144786C71924100 @default.
- W2176144786 hasConceptScore W2176144786C98274493 @default.
- W2176144786 hasIssue "8" @default.
- W2176144786 hasLocation W21761447861 @default.
- W2176144786 hasOpenAccess W2176144786 @default.
- W2176144786 hasPrimaryLocation W21761447861 @default.
- W2176144786 hasRelatedWork W1971818316 @default.
- W2176144786 hasRelatedWork W2322833898 @default.
- W2176144786 hasRelatedWork W2386590639 @default.
- W2176144786 hasRelatedWork W2389662014 @default.
- W2176144786 hasRelatedWork W2394203161 @default.
- W2176144786 hasRelatedWork W2413988442 @default.
- W2176144786 hasRelatedWork W2417433543 @default.
- W2176144786 hasRelatedWork W2620705974 @default.
- W2176144786 hasRelatedWork W2790134474 @default.
- W2176144786 hasRelatedWork W3005360611 @default.
- W2176144786 hasRelatedWork W3024520031 @default.
- W2176144786 hasRelatedWork W3028640797 @default.
- W2176144786 hasRelatedWork W3028806580 @default.
- W2176144786 hasRelatedWork W3028902680 @default.
- W2176144786 hasRelatedWork W3030347623 @default.
- W2176144786 hasRelatedWork W3030641892 @default.
- W2176144786 hasRelatedWork W3030997918 @default.
- W2176144786 hasRelatedWork W3032399921 @default.
- W2176144786 hasRelatedWork W3032504968 @default.
- W2176144786 hasRelatedWork W3141111096 @default.
- W2176144786 hasVolume "10" @default.
- W2176144786 isParatext "false" @default.
- W2176144786 isRetracted "false" @default.
- W2176144786 magId "2176144786" @default.
- W2176144786 workType "article" @default.