FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2176200829> ?p ?o ?g. }

• W2176200829 abstract "Disseminated tumor cells (DTCs) can be detected using ultrasensitive immunocytochemical assays and their presence in the bone marrow can predict the subsequent occurrence of overt metastasis formation and metastatic relapse. Using expression profiling on early stage primary breast tumors, low IRX2 expression was previously shown to be associated with the presence of DTCs in the bone marrow, suggesting a possible role of IRX2 in the early steps of metastasis formation. The purpose of this study is to gain insights into the significance of IRX2 protein function in the progression of breast cancer. To assess the physiological relevance of IRX2 in breast cancer, we evaluated IRX2 expression in a large breast cancer cohort (n = 1992). Additionally, constitutive IRX2 over expression was established in BT-549 and Hs578T breast cancer cell lines. Subsequently we analyzed whether IRX2 overexpression effects chemokine secretion and cellular motility of these cells. Low IRX2 mRNA expression was found to correlate with high tumor grade, positive lymph node status, negative hormone receptor status, and basal type of primary breast tumors. Also in cell lines low IRX2 expression was associated with mainly basal breast cancer cell lines. The functional studies show that overexpression of the IRX2 transcription factor in basal cell lines suppressed secretion of the pro-metastatic chemokines and inhibited cellular motility but did not influence cell proliferation. Our results imply that the IRX2 transcription factor might represent a novel metastasis associated protein that acts as a negative regulator of cellular motility and as a repressor of chemokine expression. Loss of IRX2 expression could therefore contribute to early hematogenous dissemination of breast cancer by sustaining chemokine secretion and enabling mobilization of tumor cells." @default.
• W2176200829 created "2016-06-24" @default.
• W2176200829 creator A5004438035 @default.
• W2176200829 creator A5019571457 @default.
• W2176200829 creator A5048105827 @default.
• W2176200829 creator A5057450854 @default.
• W2176200829 creator A5078834232 @default.
• W2176200829 creator A5084893201 @default.
• W2176200829 creator A5085016405 @default.
• W2176200829 date "2015-11-11" @default.
• W2176200829 modified "2023-10-14" @default.
• W2176200829 title "Iroquois homeobox 2 suppresses cellular motility and chemokine expression in breast cancer cells" @default.
• W2176200829 cites W1522560282 @default.
• W2176200829 cites W1972132727 @default.
• W2176200829 cites W1994197368 @default.
• W2176200829 cites W2005895632 @default.
• W2176200829 cites W2014260136 @default.
• W2176200829 cites W2018781502 @default.
• W2176200829 cites W2037493777 @default.
• W2176200829 cites W2046376502 @default.
• W2176200829 cites W2054017641 @default.
• W2176200829 cites W2063140987 @default.
• W2176200829 cites W2064873657 @default.
• W2176200829 cites W2068503417 @default.
• W2176200829 cites W2069207808 @default.
• W2176200829 cites W2070997916 @default.
• W2176200829 cites W2071867803 @default.
• W2176200829 cites W2098748394 @default.
• W2176200829 cites W2100592123 @default.
• W2176200829 cites W2116455112 @default.
• W2176200829 cites W2120241672 @default.
• W2176200829 cites W2135095550 @default.
• W2176200829 cites W2135558815 @default.
• W2176200829 cites W2141670332 @default.
• W2176200829 cites W2141815918 @default.
• W2176200829 cites W2142739240 @default.
• W2176200829 cites W2146415477 @default.
• W2176200829 cites W2149483845 @default.
• W2176200829 cites W2150533948 @default.
• W2176200829 cites W2158217645 @default.
• W2176200829 cites W2163679779 @default.
• W2176200829 cites W2167165223 @default.
• W2176200829 cites W2167925037 @default.
• W2176200829 cites W4232037809 @default.
• W2176200829 cites W4253074478 @default.
• W2176200829 doi "https://doi.org/10.1186/s12885-015-1907-4" @default.
• W2176200829 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4642646" @default.
• W2176200829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26560478" @default.
• W2176200829 hasPublicationYear "2015" @default.
• W2176200829 type Work @default.
• W2176200829 sameAs 2176200829 @default.
• W2176200829 citedByCount "15" @default.
• W2176200829 countsByYear W21762008292016 @default.
• W2176200829 countsByYear W21762008292018 @default.
• W2176200829 countsByYear W21762008292019 @default.
• W2176200829 countsByYear W21762008292020 @default.
• W2176200829 countsByYear W21762008292022 @default.
• W2176200829 countsByYear W21762008292023 @default.
• W2176200829 crossrefType "journal-article" @default.
• W2176200829 hasAuthorship W2176200829A5004438035 @default.
• W2176200829 hasAuthorship W2176200829A5019571457 @default.
• W2176200829 hasAuthorship W2176200829A5048105827 @default.
• W2176200829 hasAuthorship W2176200829A5057450854 @default.
• W2176200829 hasAuthorship W2176200829A5078834232 @default.
• W2176200829 hasAuthorship W2176200829A5084893201 @default.
• W2176200829 hasAuthorship W2176200829A5085016405 @default.
• W2176200829 hasBestOaLocation W21762008291 @default.
• W2176200829 hasConcept C121608353 @default.
• W2176200829 hasConcept C126322002 @default.
• W2176200829 hasConcept C12823836 @default.
• W2176200829 hasConcept C13373296 @default.
• W2176200829 hasConcept C143998085 @default.
• W2176200829 hasConcept C170493617 @default.
• W2176200829 hasConcept C2779013556 @default.
• W2176200829 hasConcept C502942594 @default.
• W2176200829 hasConcept C530470458 @default.
• W2176200829 hasConcept C58207958 @default.
• W2176200829 hasConcept C71924100 @default.
• W2176200829 hasConcept C86803240 @default.
• W2176200829 hasConcept C95444343 @default.
• W2176200829 hasConceptScore W2176200829C121608353 @default.
• W2176200829 hasConceptScore W2176200829C126322002 @default.
• W2176200829 hasConceptScore W2176200829C12823836 @default.
• W2176200829 hasConceptScore W2176200829C13373296 @default.
• W2176200829 hasConceptScore W2176200829C143998085 @default.
• W2176200829 hasConceptScore W2176200829C170493617 @default.
• W2176200829 hasConceptScore W2176200829C2779013556 @default.
• W2176200829 hasConceptScore W2176200829C502942594 @default.
• W2176200829 hasConceptScore W2176200829C530470458 @default.
• W2176200829 hasConceptScore W2176200829C58207958 @default.
• W2176200829 hasConceptScore W2176200829C71924100 @default.
• W2176200829 hasConceptScore W2176200829C86803240 @default.
• W2176200829 hasConceptScore W2176200829C95444343 @default.
• W2176200829 hasFunder F4320320300 @default.
• W2176200829 hasIssue "1" @default.
• W2176200829 hasLocation W21762008291 @default.
• W2176200829 hasLocation W21762008292 @default.
• W2176200829 hasLocation W21762008293 @default.
• W2176200829 hasLocation W21762008294 @default.
• W2176200829 hasOpenAccess W2176200829 @default.

• next