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- W2176228859 endingPage "R36" @default.
- W2176228859 startingPage "R23" @default.
- W2176228859 abstract "Bone is a dynamic tissue that undergoes constant remodeling. The appropriate course of this process determines development and regeneration of the skeleton. Tight molecular control of bone remodeling is vital for the maintenance of appropriate physiology and microarchitecture of the bone, providing homeostasis, also at the systemic level. The process of remodeling is regulated by a rich innervation of the skeleton, being the source of various growth factors, neurotransmitters, and hormones regulating function of the bone. Although the course of bone remodeling at the cellular level is mainly associated with the activity of osteoclasts and osteoblasts, recently also osteocytes have gained a growing interest as the principal regulators of bone turnover. Osteocytes play a significant role in the regulation of osteogenesis, releasing sclerostin (SOST), an inhibitor of bone formation. The process of bone turnover, especially osteogenesis, is also modulated by extra-skeletal molecules. Proliferation and differentiation of osteoblasts are promoted by the brain-derived serotonin and hypothetically inhibited by its intestinal equivalent. The activity of SOST and serotonin is either directly or indirectly associated with the canonical Wnt/β-catenin signaling pathway, the main regulatory pathway of osteoblasts function. The impairment of bone remodeling may lead to many skeletal diseases, such as high bone mass syndrome or osteoporosis. In this paper, we review the most recent data on the cellular and molecular mechanisms of bone remodeling control, with particular emphasis on the role of osteocytes and the nervous system in this process." @default.
- W2176228859 created "2016-06-24" @default.
- W2176228859 creator A5002538716 @default.
- W2176228859 creator A5057668877 @default.
- W2176228859 date "2015-08-24" @default.
- W2176228859 modified "2023-09-23" @default.
- W2176228859 title "Bone remodeling in the context of cellular and systemic regulation: the role of osteocytes and the nervous system" @default.
- W2176228859 cites W114554199 @default.
- W2176228859 cites W1512617915 @default.
- W2176228859 cites W1516916106 @default.
- W2176228859 cites W1522565977 @default.
- W2176228859 cites W1577996279 @default.
- W2176228859 cites W1911703092 @default.
- W2176228859 cites W1963686806 @default.
- W2176228859 cites W1967275901 @default.
- W2176228859 cites W1969806900 @default.
- W2176228859 cites W1970864109 @default.
- W2176228859 cites W1972877115 @default.
- W2176228859 cites W1972994473 @default.
- W2176228859 cites W1975953388 @default.
- W2176228859 cites W1976402969 @default.
- W2176228859 cites W1981465641 @default.
- W2176228859 cites W1981582225 @default.
- W2176228859 cites W1982395713 @default.
- W2176228859 cites W1983944082 @default.
- W2176228859 cites W1984332525 @default.
- W2176228859 cites W1986085728 @default.
- W2176228859 cites W1986536127 @default.
- W2176228859 cites W1991231767 @default.
- W2176228859 cites W1992722635 @default.
- W2176228859 cites W1994404723 @default.
- W2176228859 cites W1997336067 @default.
- W2176228859 cites W1997425731 @default.
- W2176228859 cites W1997508587 @default.
- W2176228859 cites W1998836977 @default.
- W2176228859 cites W2000398693 @default.
- W2176228859 cites W2002219555 @default.
- W2176228859 cites W2003067766 @default.
- W2176228859 cites W2007942855 @default.
- W2176228859 cites W2008187259 @default.
- W2176228859 cites W2013184426 @default.
- W2176228859 cites W2013309414 @default.
- W2176228859 cites W2013644255 @default.
- W2176228859 cites W2019196925 @default.
- W2176228859 cites W2021115829 @default.
- W2176228859 cites W2022371338 @default.
- W2176228859 cites W2025371271 @default.
- W2176228859 cites W2027795585 @default.
- W2176228859 cites W2028910660 @default.
- W2176228859 cites W2031130917 @default.
- W2176228859 cites W2031908008 @default.
- W2176228859 cites W2033006509 @default.
- W2176228859 cites W2033114086 @default.
- W2176228859 cites W2033861612 @default.
- W2176228859 cites W2037750372 @default.
- W2176228859 cites W2037976951 @default.
- W2176228859 cites W2037978897 @default.
- W2176228859 cites W2039101705 @default.
- W2176228859 cites W2042353520 @default.
- W2176228859 cites W2043288146 @default.
- W2176228859 cites W2043991983 @default.
- W2176228859 cites W2045524992 @default.
- W2176228859 cites W2046882967 @default.
- W2176228859 cites W2051202218 @default.
- W2176228859 cites W2051577992 @default.
- W2176228859 cites W2053352622 @default.
- W2176228859 cites W2059323353 @default.
- W2176228859 cites W2060235532 @default.
- W2176228859 cites W2064729399 @default.
- W2176228859 cites W2067133247 @default.
- W2176228859 cites W2069543462 @default.
- W2176228859 cites W2073052871 @default.
- W2176228859 cites W2073907573 @default.
- W2176228859 cites W2074898328 @default.
- W2176228859 cites W2076974856 @default.
- W2176228859 cites W2078219318 @default.
- W2176228859 cites W2079076173 @default.
- W2176228859 cites W2079930274 @default.
- W2176228859 cites W2086694435 @default.
- W2176228859 cites W2087560312 @default.
- W2176228859 cites W2087566569 @default.
- W2176228859 cites W2087665466 @default.
- W2176228859 cites W2091578240 @default.
- W2176228859 cites W2093625328 @default.
- W2176228859 cites W2095703370 @default.
- W2176228859 cites W2096627331 @default.
- W2176228859 cites W2103198077 @default.
- W2176228859 cites W2107215516 @default.
- W2176228859 cites W2108403721 @default.
- W2176228859 cites W2114589447 @default.
- W2176228859 cites W2114649090 @default.
- W2176228859 cites W2118375575 @default.
- W2176228859 cites W2118807251 @default.
- W2176228859 cites W2119221073 @default.
- W2176228859 cites W2119284420 @default.
- W2176228859 cites W2119538166 @default.
- W2176228859 cites W2119934014 @default.
- W2176228859 cites W2131862834 @default.