Matches in SemOpenAlex for { <https://semopenalex.org/work/W2176236707> ?p ?o ?g. }
- W2176236707 endingPage "678" @default.
- W2176236707 startingPage "666" @default.
- W2176236707 abstract "Abstract Although most adults can lose weight by dieting, a well-characterized compensatory decrease in energy expenditure promotes weight regain more than 90% of the time. Using mice with impaired hypothalamic leptin signaling as a model of early-onset hyperphagia and obesity, we explored whether this unfavorable response to weight loss could be circumvented by early intervention. Early-onset obesity was associated with impairments in the structure and function of brown adipose tissue mitochondria, which were ameliorated by weight loss at any age. Although decreased sympathetic tone in weight-reduced adults resulted in net reductions in brown adipose tissue thermogenesis and energy expenditure that promoted rapid weight regain, this was not the case when dietary interventions were initiated at weaning. Enhanced energy expenditure persisted even after mice were allowed to resume overeating, leading to lasting reductions in adiposity. These findings reveal a time window when dietary interventions can produce metabolic improvements that are stably maintained." @default.
- W2176236707 created "2016-06-24" @default.
- W2176236707 creator A5003734252 @default.
- W2176236707 creator A5022032913 @default.
- W2176236707 creator A5048106828 @default.
- W2176236707 creator A5064862540 @default.
- W2176236707 creator A5068028435 @default.
- W2176236707 creator A5068645871 @default.
- W2176236707 creator A5080068924 @default.
- W2176236707 date "2015-11-20" @default.
- W2176236707 modified "2023-10-17" @default.
- W2176236707 title "Reducing Adiposity in a Critical Developmental Window Has Lasting Benefits in Mice" @default.
- W2176236707 cites W1544688980 @default.
- W2176236707 cites W1623857162 @default.
- W2176236707 cites W1672199487 @default.
- W2176236707 cites W1740243919 @default.
- W2176236707 cites W184177557 @default.
- W2176236707 cites W1878039167 @default.
- W2176236707 cites W1978264573 @default.
- W2176236707 cites W1979276079 @default.
- W2176236707 cites W1986333814 @default.
- W2176236707 cites W1995322713 @default.
- W2176236707 cites W1999310337 @default.
- W2176236707 cites W2014674498 @default.
- W2176236707 cites W2019451885 @default.
- W2176236707 cites W2020836763 @default.
- W2176236707 cites W2028235083 @default.
- W2176236707 cites W2034756769 @default.
- W2176236707 cites W2042109173 @default.
- W2176236707 cites W2047936342 @default.
- W2176236707 cites W2050359315 @default.
- W2176236707 cites W2052551956 @default.
- W2176236707 cites W2056469402 @default.
- W2176236707 cites W2060138288 @default.
- W2176236707 cites W2061777482 @default.
- W2176236707 cites W2062073832 @default.
- W2176236707 cites W2064695336 @default.
- W2176236707 cites W2067893382 @default.
- W2176236707 cites W2070283453 @default.
- W2176236707 cites W2071045528 @default.
- W2176236707 cites W2074235161 @default.
- W2176236707 cites W2077068997 @default.
- W2176236707 cites W2079687627 @default.
- W2176236707 cites W2086361374 @default.
- W2176236707 cites W2087832934 @default.
- W2176236707 cites W2089776720 @default.
- W2176236707 cites W2090788513 @default.
- W2176236707 cites W2090796440 @default.
- W2176236707 cites W2090861392 @default.
- W2176236707 cites W2091434385 @default.
- W2176236707 cites W2091458721 @default.
- W2176236707 cites W2093900205 @default.
- W2176236707 cites W2096114331 @default.
- W2176236707 cites W2097879976 @default.
- W2176236707 cites W2103843557 @default.
- W2176236707 cites W2104032941 @default.
- W2176236707 cites W2104593840 @default.
- W2176236707 cites W2105761638 @default.
- W2176236707 cites W2112451262 @default.
- W2176236707 cites W2115824298 @default.
- W2176236707 cites W2121948264 @default.
- W2176236707 cites W2125467434 @default.
- W2176236707 cites W2127225704 @default.
- W2176236707 cites W2130422635 @default.
- W2176236707 cites W2132358997 @default.
- W2176236707 cites W2133865500 @default.
- W2176236707 cites W2137746966 @default.
- W2176236707 cites W2137971928 @default.
- W2176236707 cites W2140708883 @default.
- W2176236707 cites W2143586230 @default.
- W2176236707 cites W2153577602 @default.
- W2176236707 cites W2153816623 @default.
- W2176236707 cites W2158399663 @default.
- W2176236707 cites W2159171444 @default.
- W2176236707 cites W2161728519 @default.
- W2176236707 cites W2161780869 @default.
- W2176236707 cites W2167151437 @default.
- W2176236707 cites W2185793661 @default.
- W2176236707 cites W2202074724 @default.
- W2176236707 cites W2203125735 @default.
- W2176236707 cites W2234762463 @default.
- W2176236707 cites W2283488063 @default.
- W2176236707 cites W2293795295 @default.
- W2176236707 cites W2304450380 @default.
- W2176236707 cites W2316534927 @default.
- W2176236707 cites W2321598419 @default.
- W2176236707 cites W2324334195 @default.
- W2176236707 cites W2404674278 @default.
- W2176236707 cites W2416243334 @default.
- W2176236707 cites W2419087118 @default.
- W2176236707 cites W2431113823 @default.
- W2176236707 cites W4296793052 @default.
- W2176236707 cites W94238326 @default.
- W2176236707 cites W2397007498 @default.
- W2176236707 doi "https://doi.org/10.1210/en.2015-1753" @default.
- W2176236707 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4733128" @default.
- W2176236707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26587784" @default.
- W2176236707 hasPublicationYear "2015" @default.