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• W2176248001 abstract "Research Article1 July 1992free access The ‘second-codon rule’ and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes. M. Nishizawa M. Nishizawa Division of Molecular Genetics, Kurume University, Fukuoka, Japan. Search for more papers by this author K. Okazaki K. Okazaki Division of Molecular Genetics, Kurume University, Fukuoka, Japan. Search for more papers by this author N. Furuno N. Furuno Division of Molecular Genetics, Kurume University, Fukuoka, Japan. Search for more papers by this author N. Watanabe N. Watanabe Division of Molecular Genetics, Kurume University, Fukuoka, Japan. Search for more papers by this author N. Sagata N. Sagata Division of Molecular Genetics, Kurume University, Fukuoka, Japan. Search for more papers by this author M. Nishizawa M. Nishizawa Division of Molecular Genetics, Kurume University, Fukuoka, Japan. Search for more papers by this author K. Okazaki K. Okazaki Division of Molecular Genetics, Kurume University, Fukuoka, Japan. Search for more papers by this author N. Furuno N. Furuno Division of Molecular Genetics, Kurume University, Fukuoka, Japan. Search for more papers by this author N. Watanabe N. Watanabe Division of Molecular Genetics, Kurume University, Fukuoka, Japan. Search for more papers by this author N. Sagata N. Sagata Division of Molecular Genetics, Kurume University, Fukuoka, Japan. Search for more papers by this author Author Information M. Nishizawa1, K. Okazaki1, N. Furuno1, N. Watanabe1 and N. Sagata1 1Division of Molecular Genetics, Kurume University, Fukuoka, Japan. The EMBO Journal (1992)11:2433-2446https://doi.org/10.1002/j.1460-2075.1992.tb05308.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The c-mos proto-oncogene product, Mos, functions in both early (germinal vesicle breakdown) and late (metaphase II arrest) steps during meiotic maturation in Xenopus oocytes. In the early step, Mos is only partially phosphorylated and metabolically unstable, while in the late step it is fully phosphorylated and highly stable. Using a number of Mos mutants expressed in oocytes, we show here that the instability of Mos in the early step is determined primarily by its penultimate N-terminal residue, or by a rule referred to here as the ‘second-codon rule’. We demonstrate that unstable Mos is degraded by the ubiquitin-dependent pathway. In the late step, on the other hand, Mos is stabilized by autophosphorylation at Ser3, which probably acts to prevent the N-terminus of Mos from being recognized by a ubiquitin-protein ligase. Moreover, we show that Ser3 phosphorylation is essential for Mos to exert its full cytostatic factor (CSF) activity in fully mature oocytes. Thus, a few N-terminal amino acids are primary determinants of both the metabolic stability and physiological activity of Mos during the meiotic cell cycle. Previous ArticleNext Article Volume 11Issue 71 July 1992In this issue RelatedDetailsLoading ..." @default.
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• W2176248001 date "1992-07-01" @default.
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• W2176248001 title "The ‘second-codon rule’ and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes." @default.
• W2176248001 cites W1479851678 @default.
• W2176248001 cites W1489931243 @default.
• W2176248001 cites W1493816947 @default.
• W2176248001 cites W1496172532 @default.
• W2176248001 cites W1504158642 @default.
• W2176248001 cites W1519470329 @default.
• W2176248001 cites W1529813906 @default.
• W2176248001 cites W1535473877 @default.
• W2176248001 cites W1543158853 @default.
• W2176248001 cites W1550151833 @default.
• W2176248001 cites W1557428740 @default.
• W2176248001 cites W1566158288 @default.
• W2176248001 cites W1712945520 @default.
• W2176248001 cites W1829184050 @default.
• W2176248001 cites W1969336855 @default.
• W2176248001 cites W1972279307 @default.
• W2176248001 cites W1978232160 @default.
• W2176248001 cites W1983940060 @default.
• W2176248001 cites W1984269514 @default.
• W2176248001 cites W1987045539 @default.
• W2176248001 cites W1989575075 @default.
• W2176248001 cites W1990148399 @default.
• W2176248001 cites W1991101546 @default.
• W2176248001 cites W1993834457 @default.
• W2176248001 cites W1995430236 @default.
• W2176248001 cites W1999503975 @default.
• W2176248001 cites W2002721919 @default.
• W2176248001 cites W2005634497 @default.
• W2176248001 cites W2005852971 @default.
• W2176248001 cites W2010238435 @default.
• W2176248001 cites W2010394043 @default.
• W2176248001 cites W2011039500 @default.
• W2176248001 cites W2011882215 @default.
• W2176248001 cites W2012781224 @default.
• W2176248001 cites W2015598117 @default.
• W2176248001 cites W2019483948 @default.
• W2176248001 cites W2021637215 @default.
• W2176248001 cites W2022705531 @default.
• W2176248001 cites W2023584657 @default.
• W2176248001 cites W2024666493 @default.
• W2176248001 cites W2032413267 @default.
• W2176248001 cites W2037426608 @default.
• W2176248001 cites W203877970 @default.
• W2176248001 cites W2039643632 @default.
• W2176248001 cites W2041074116 @default.
• W2176248001 cites W2042869569 @default.
• W2176248001 cites W2055037221 @default.
• W2176248001 cites W2059623287 @default.
• W2176248001 cites W2062663235 @default.
• W2176248001 cites W2066666058 @default.
• W2176248001 cites W2067397983 @default.
• W2176248001 cites W2067656276 @default.
• W2176248001 cites W2071056869 @default.
• W2176248001 cites W2072720547 @default.
• W2176248001 cites W2074423119 @default.
• W2176248001 cites W2077086653 @default.
• W2176248001 cites W2078030700 @default.
• W2176248001 cites W2081182298 @default.
• W2176248001 cites W2084136914 @default.
• W2176248001 cites W2092198543 @default.
• W2176248001 cites W2102242413 @default.
• W2176248001 cites W2103174300 @default.
• W2176248001 cites W2104404316 @default.
• W2176248001 cites W2105050778 @default.
• W2176248001 cites W2117939247 @default.
• W2176248001 cites W2119137218 @default.
• W2176248001 cites W2123930515 @default.
• W2176248001 cites W2127283099 @default.
• W2176248001 cites W2162807364 @default.
• W2176248001 cites W2168847939 @default.
• W2176248001 cites W2169996826 @default.
• W2176248001 cites W2337808527 @default.
• W2176248001 cites W2396104867 @default.
• W2176248001 cites W2423394250 @default.
• W2176248001 cites W37841377 @default.
• W2176248001 cites W4211135707 @default.
• W2176248001 cites W987526729 @default.
• W2176248001 doi "https://doi.org/10.1002/j.1460-2075.1992.tb05308.x" @default.
• W2176248001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/556718" @default.
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