Matches in SemOpenAlex for { <https://semopenalex.org/work/W2176287059> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2176287059 endingPage "93" @default.
- W2176287059 startingPage "285" @default.
- W2176287059 abstract "Specific immune responses of inbred miniature pigs following vaccination and challenge with suid herpesvirus 1 (SHV-1) were determined. Vaccination of swine with SHV-1 elicited both specific neutralizing antibody and lymphoproliferative responses. Moreover, pigs vaccinated with SHV-1 were fully protected against a lethal virus challenge. Pigs vaccinated with a recombinant (r) SHV-1 virus, followed by challenge with a virulent SHV-1, had lower percentages of circulating T- and B-lymphocytes, and showed a significant (P < or = 0.05) reduction in peripheral blood mononuclear cell (PBMC) antibody-dependent cell-cytotoxicity than control (noninfected, SHV-1 sero-negative) animals. From the 5th through the 8th week of postchallenge, rSHV-1 was isolated from 2 of 4 pigs. Presence of r-virus was indicative that PBMC were infectious in vivo. The rSHV-1, with beta-galactosidase activity, was only recovered from ConA- and IL-2-stimulated primary PBMC cocultivated with porcine kidney cells. Control pigs exposed to challenge SHV-1 elicited both specific neutralizing antibody and lympho-proliferative responses followed by subsequent infection. These infected pigs, compared to control pigs, had significantly (P < or = 0.05) lowered percentages of T- and B-lymphocytes, lowered T-cell mitogenic responses, variable PBMC counts, and lowered blood phagocytic cell function. When PBMC from control pigs were cultured and infected with SHV-1, the virus caused a significant (P < or = 0.05) suppression of T-cell proliferation and PBMC mitochondrial dehydrogenase and macrophage activities." @default.
- W2176287059 created "2016-06-24" @default.
- W2176287059 creator A5032298183 @default.
- W2176287059 date "1995-10-01" @default.
- W2176287059 modified "2023-09-23" @default.
- W2176287059 title "Study of immune function in inbred miniature pigs vaccinated and challenged with suid herpesvirus 1." @default.
- W2176287059 cites W1490877074 @default.
- W2176287059 cites W1542468826 @default.
- W2176287059 cites W1674177895 @default.
- W2176287059 cites W1760934554 @default.
- W2176287059 cites W1958625868 @default.
- W2176287059 cites W1964417328 @default.
- W2176287059 cites W1968213454 @default.
- W2176287059 cites W1971431856 @default.
- W2176287059 cites W1976745468 @default.
- W2176287059 cites W1984907346 @default.
- W2176287059 cites W1987722323 @default.
- W2176287059 cites W1993051112 @default.
- W2176287059 cites W2000147682 @default.
- W2176287059 cites W2002399929 @default.
- W2176287059 cites W2009473574 @default.
- W2176287059 cites W2016858932 @default.
- W2176287059 cites W2018562065 @default.
- W2176287059 cites W2037353226 @default.
- W2176287059 cites W2047962538 @default.
- W2176287059 cites W2060409674 @default.
- W2176287059 cites W2071895034 @default.
- W2176287059 cites W2075369442 @default.
- W2176287059 cites W2081872158 @default.
- W2176287059 cites W2083508704 @default.
- W2176287059 cites W2091803630 @default.
- W2176287059 cites W2140927361 @default.
- W2176287059 cites W2141833611 @default.
- W2176287059 cites W2269328436 @default.
- W2176287059 cites W2413915951 @default.
- W2176287059 cites W61011451 @default.
- W2176287059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1263783" @default.
- W2176287059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8548690" @default.
- W2176287059 hasPublicationYear "1995" @default.
- W2176287059 type Work @default.
- W2176287059 sameAs 2176287059 @default.
- W2176287059 citedByCount "1" @default.
- W2176287059 crossrefType "journal-article" @default.
- W2176287059 hasAuthorship W2176287059A5032298183 @default.
- W2176287059 hasConcept C137061746 @default.
- W2176287059 hasConcept C159047783 @default.
- W2176287059 hasConcept C159654299 @default.
- W2176287059 hasConcept C202751555 @default.
- W2176287059 hasConcept C203014093 @default.
- W2176287059 hasConcept C2522874641 @default.
- W2176287059 hasConcept C2776090121 @default.
- W2176287059 hasConcept C2776969849 @default.
- W2176287059 hasConcept C2779261636 @default.
- W2176287059 hasConcept C55493867 @default.
- W2176287059 hasConcept C86803240 @default.
- W2176287059 hasConcept C8891405 @default.
- W2176287059 hasConceptScore W2176287059C137061746 @default.
- W2176287059 hasConceptScore W2176287059C159047783 @default.
- W2176287059 hasConceptScore W2176287059C159654299 @default.
- W2176287059 hasConceptScore W2176287059C202751555 @default.
- W2176287059 hasConceptScore W2176287059C203014093 @default.
- W2176287059 hasConceptScore W2176287059C2522874641 @default.
- W2176287059 hasConceptScore W2176287059C2776090121 @default.
- W2176287059 hasConceptScore W2176287059C2776969849 @default.
- W2176287059 hasConceptScore W2176287059C2779261636 @default.
- W2176287059 hasConceptScore W2176287059C55493867 @default.
- W2176287059 hasConceptScore W2176287059C86803240 @default.
- W2176287059 hasConceptScore W2176287059C8891405 @default.
- W2176287059 hasIssue "4" @default.
- W2176287059 hasLocation W21762870591 @default.
- W2176287059 hasOpenAccess W2176287059 @default.
- W2176287059 hasPrimaryLocation W21762870591 @default.
- W2176287059 hasRelatedWork W1963815315 @default.
- W2176287059 hasRelatedWork W2010420018 @default.
- W2176287059 hasRelatedWork W2043102346 @default.
- W2176287059 hasRelatedWork W2045225156 @default.
- W2176287059 hasRelatedWork W2139983200 @default.
- W2176287059 hasRelatedWork W2144784771 @default.
- W2176287059 hasRelatedWork W2144985768 @default.
- W2176287059 hasRelatedWork W2146274173 @default.
- W2176287059 hasRelatedWork W2170726221 @default.
- W2176287059 hasRelatedWork W2313414779 @default.
- W2176287059 hasVolume "59" @default.
- W2176287059 isParatext "false" @default.
- W2176287059 isRetracted "false" @default.
- W2176287059 magId "2176287059" @default.
- W2176287059 workType "article" @default.