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- W2176353450 abstract "The C4'-oxidized abasic site (C4-AP) is produced by a variety of DNA damaging agents. This alkali labile lesion can exist in up to four diastereomeric cyclic forms, in addition to the acyclic keto-aldehyde. Synthetic oligonucleotides containing the lesion were prepared from a stable photochemical precursor. Chemical integrity of the lesion containing oligonucleotides was probed using phosphodiesterase lability. Analysis of the 3',5'-phosphate diester of the monomeric lesion released from single diastereomers of photolabile precursors by 1H NMR indicates that isomerization of the hemiacetal and/or hemiketal is rapid. The syntheses and characterization of oligonucleotides containing configurationally stable analogues of C4-AP, which serve as mechanistic probes for deciphering the structural basis of the biochemical and biological effects of the C4'-oxidized abasic lesion, are also described." @default.
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- W2176353450 date "2005-09-01" @default.
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- W2176353450 title "Preparation and Analysis of Oligonucleotides Containing the C4‘-Oxidized Abasic Site and Related Mechanistic Probes" @default.
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- W2176353450 doi "https://doi.org/10.1021/jo0512249" @default.
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