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• W2176372170 abstract "Based on lead compounds 2 and 3 a series of 3,5-disubstituted pyridines have been designed and evaluated for inhibition of AKT/PKB. Modifications at the 3 position of the pyridine ring led to a number of potent compounds with improved physical properties, resulting in the identification of 11g as a promising, orally active Akt inhibitor. The synthesis, structure–activity relationship studies, and pharmacokinetic data are presented in this paper." @default.
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• W2176372170 date "2006-07-01" @default.
• W2176372170 modified "2023-10-12" @default.
• W2176372170 title "Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase" @default.
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• W2176372170 doi "https://doi.org/10.1016/j.bmcl.2006.04.046" @default.
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