FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2176445246> ?p ?o ?g. }

• W2176445246 endingPage "83" @default.
• W2176445246 startingPage "77" @default.
• W2176445246 abstract "The translocator protein (18 kDa) (TSPO) plays an important role in stress-related disorders, such as anxiety, depression and post-traumatic stress disorder (PTSD), caused by neurosteroids (e.g. allopregnanolone). The present study sought to evaluate the significance of TSPO in anxiolytic and antidepressant effects induced by midazolam. The animals were administrated midazolam (0.25, 0.5 and 1 mg/kg, i.p.) and subjected to behavioral tests, including Vogel-type conflict test, elevated plus-maze test, forced swimming test. Midazolam produced anxiolytic- and antidepressant-like effects Vogel-type conflict test (1 mg/kg, i.p.), elevated plus-maze test (0.5 and 1 mg/kg, i.p.), and forced swimming test (0.5 and 1 mg/kg, i.p.). These effects of Midazolam were totally blocked by the TSPO antagonist PK11195 (3 mg/kg, i.p.). To evaluate the role of allopregnanolone in the anxiolytic- and antidepressant-like effects of midazolam, the animals were decapitated at the end of the behavioral tests. The allopregnanolone levels of the prefrontal cortex and hippocampus were measured by enzyme-linked immunosorbent assay (ELISA). The allopregnanolone level of the prefrontal cortex and hippocampus was increased by midazolam (0.5, 1 mg/kg, i.p.) and the increase was reversed by PK11195 (3 mg/kg, i.p.). Overall, the results indicated that the anxiolytic- and antidepressant-like effects of midazolam were mediated by TSPO, via stimulation of allopregnanolone biosynthesis." @default.
• W2176445246 created "2016-06-24" @default.
• W2176445246 creator A5007601410 @default.
• W2176445246 creator A5009613920 @default.
• W2176445246 creator A5036821761 @default.
• W2176445246 creator A5038805449 @default.
• W2176445246 creator A5043178010 @default.
• W2176445246 creator A5043948395 @default.
• W2176445246 creator A5051829015 @default.
• W2176445246 creator A5052912120 @default.
• W2176445246 creator A5067544921 @default.
• W2176445246 creator A5069368379 @default.
• W2176445246 creator A5077949575 @default.
• W2176445246 creator A5085462851 @default.
• W2176445246 creator A5085960166 @default.
• W2176445246 date "2015-12-01" @default.
• W2176445246 modified "2023-10-01" @default.
• W2176445246 title "Translocator protein mediates the anxiolytic and antidepressant effects of midazolam" @default.
• W2176445246 cites W1508849773 @default.
• W2176445246 cites W1572438763 @default.
• W2176445246 cites W1590242628 @default.
• W2176445246 cites W1965172024 @default.
• W2176445246 cites W1984582983 @default.
• W2176445246 cites W1987253310 @default.
• W2176445246 cites W1989501319 @default.
• W2176445246 cites W1993177267 @default.
• W2176445246 cites W1994730852 @default.
• W2176445246 cites W1997933872 @default.
• W2176445246 cites W2000945972 @default.
• W2176445246 cites W2002862204 @default.
• W2176445246 cites W2002863546 @default.
• W2176445246 cites W2010432790 @default.
• W2176445246 cites W2011689952 @default.
• W2176445246 cites W2017794013 @default.
• W2176445246 cites W2024344189 @default.
• W2176445246 cites W2031094958 @default.
• W2176445246 cites W2031648971 @default.
• W2176445246 cites W2034450620 @default.
• W2176445246 cites W2037631502 @default.
• W2176445246 cites W2040115686 @default.
• W2176445246 cites W2043915680 @default.
• W2176445246 cites W2044883179 @default.
• W2176445246 cites W2055973066 @default.
• W2176445246 cites W2058379934 @default.
• W2176445246 cites W2068449302 @default.
• W2176445246 cites W2068863915 @default.
• W2176445246 cites W2075895907 @default.
• W2176445246 cites W2079425996 @default.
• W2176445246 cites W2083785531 @default.
• W2176445246 cites W2088498973 @default.
• W2176445246 cites W2088904257 @default.
• W2176445246 cites W2092933199 @default.
• W2176445246 cites W2114243524 @default.
• W2176445246 cites W2128168682 @default.
• W2176445246 cites W2136529079 @default.
• W2176445246 cites W2140201388 @default.
• W2176445246 cites W2150718243 @default.
• W2176445246 cites W2166399477 @default.
• W2176445246 cites W577815675 @default.
• W2176445246 doi "https://doi.org/10.1016/j.pbb.2015.10.005" @default.
• W2176445246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26455280" @default.
• W2176445246 hasPublicationYear "2015" @default.
• W2176445246 type Work @default.
• W2176445246 sameAs 2176445246 @default.
• W2176445246 citedByCount "21" @default.
• W2176445246 countsByYear W21764452462016 @default.
• W2176445246 countsByYear W21764452462017 @default.
• W2176445246 countsByYear W21764452462018 @default.
• W2176445246 countsByYear W21764452462020 @default.
• W2176445246 countsByYear W21764452462021 @default.
• W2176445246 countsByYear W21764452462022 @default.
• W2176445246 countsByYear W21764452462023 @default.
• W2176445246 crossrefType "journal-article" @default.
• W2176445246 hasAuthorship W2176445246A5007601410 @default.
• W2176445246 hasAuthorship W2176445246A5009613920 @default.
• W2176445246 hasAuthorship W2176445246A5036821761 @default.
• W2176445246 hasAuthorship W2176445246A5038805449 @default.
• W2176445246 hasAuthorship W2176445246A5043178010 @default.
• W2176445246 hasAuthorship W2176445246A5043948395 @default.
• W2176445246 hasAuthorship W2176445246A5051829015 @default.
• W2176445246 hasAuthorship W2176445246A5052912120 @default.
• W2176445246 hasAuthorship W2176445246A5067544921 @default.
• W2176445246 hasAuthorship W2176445246A5069368379 @default.
• W2176445246 hasAuthorship W2176445246A5077949575 @default.
• W2176445246 hasAuthorship W2176445246A5085462851 @default.
• W2176445246 hasAuthorship W2176445246A5085960166 @default.
• W2176445246 hasConcept C118552586 @default.
• W2176445246 hasConcept C126322002 @default.
• W2176445246 hasConcept C134018914 @default.
• W2176445246 hasConcept C136569192 @default.
• W2176445246 hasConcept C142724271 @default.
• W2176445246 hasConcept C15744967 @default.
• W2176445246 hasConcept C168258287 @default.
• W2176445246 hasConcept C169760540 @default.
• W2176445246 hasConcept C169900460 @default.
• W2176445246 hasConcept C170493617 @default.
• W2176445246 hasConcept C173586616 @default.
• W2176445246 hasConcept C204787440 @default.

• next