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• W2176515087 startingPage "1812" @default.
• W2176515087 abstract "The sexes share the same autosomal genomes, yet sexual dimorphism is common due to sex-specific gene expression. When present, XX and XY karyotypes trigger alternate regulatory cascades that determine sex-specific gene expression profiles. In mammals, secretion of testosterone (T) by the testes during foetal development is the master switch influencing the gene expression pathways (male vs. female) that will be followed, but many genes have sex-specific expression prior to T secretion. Environmental factors, like endocrine disruptors and mimics, can interfere with sexual development. However, sex-specific ontogeny can be canalized by the production of epigenetic marks (epimarks) generated during early ontogeny that increase sensitivity of XY embryos to T and decrease sensitivity of XX embryos. Here, we integrate and synthesize the evidence indicating that canalizing epimarks are produced during early ontogeny. We will also describe the evidence that such epimarks sometimes carry over across generations and produce mosaicism in which some traits are discordant with the gonad. Such carryover epimarks are sexually antagonistic because they benefit the individual in which they were formed (via canalization) but harm opposite-sex offspring when they fail to erase across generations and produce gonad-trait discordances. SA-epimarks have the potential to: i) magnify phenotypic variation for many sexually selected traits, ii) generate overlap along many dimensions of the masculinity/femininity spectrum, and iii) influence medically important gonad-trait discordances like cryptorchidism, hypospadias and idiopathic hirsutism." @default.
• W2176515087 created "2016-06-24" @default.
• W2176515087 creator A5049094681 @default.
• W2176515087 creator A5056250500 @default.
• W2176515087 creator A5086869086 @default.
• W2176515087 date "2016-01-19" @default.
• W2176515087 modified "2023-10-05" @default.
• W2176515087 title "Sexually antagonistic epigenetic marks that canalize sexually dimorphic development" @default.
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• W2176515087 doi "https://doi.org/10.1111/mec.13490" @default.
• W2176515087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26600375" @default.
• W2176515087 hasPublicationYear "2016" @default.
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