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• W2176620224 endingPage "1782" @default.
• W2176620224 startingPage "1768" @default.
• W2176620224 abstract "Melphalan (L-phenylalanine mustard) is a bifunctional alkylating agent that is commonly administered orally to treat a wide variety of malignancies, including cancers of the breast and ovary, as well as multiple myeloma. Although commercially available in Europe and Canada, intravenous (IV) melphalan remains investigational in the United States. The role of IV melphalan in cancer chemotherapy is not well defined, despite its manageable toxicity and higher and more predictable blood levels following IV administration compared with oral administration. In addition, unlike oral melphalan, an extensive phase I evaluation of IV melphalan has not been undertaken. At lower doses (eg, 30 to 70 mg/m2), both as a single agent and in combination, the activity of IV melphalan has been evaluated in only a limited number of diseases. However, striking activity has been observed in previously untreated patients with rhabdomyosarcoma, a disease not generally considered responsive to alkylating agents. When administered at high doses (greater than 140 mg/m2) requiring bone marrow reinfusion, melphalan effects a high response rate (but no improvement in survival) in a variety of nonhematologic tumor types, including resistant tumors such as melanoma and colon carcinoma. In contrast, in poor-prognosis patients with non-Hodgkin's lymphoma, Hodgkin's disease, multiple myeloma, or neuroblastoma, high-dose melphalan-containing regimens have yielded both high response rates and improved survival, despite considerable toxicity. Additional clinical trials will be necessary to define the spectrum of activity of lower doses of IV melphalan and to define subgroups of patients most likely to benefit from high-dose melphalan." @default.
• W2176620224 created "2016-06-24" @default.
• W2176620224 creator A5001602434 @default.
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• W2176620224 creator A5034364793 @default.
• W2176620224 creator A5068271757 @default.
• W2176620224 date "1988-11-01" @default.
• W2176620224 modified "2023-10-02" @default.
• W2176620224 title "The systemic administration of intravenous melphalan." @default.
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• W2176620224 doi "https://doi.org/10.1200/jco.1988.6.11.1768" @default.
• W2176620224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3054005" @default.
• W2176620224 hasPublicationYear "1988" @default.
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