FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2176704368> ?p ?o ?g. }

• W2176704368 endingPage "282" @default.
• W2176704368 startingPage "272" @default.
• W2176704368 abstract "Turcotte, S. and Averill-Bates, D. A. Sensitization to the Cytotoxicity of Melphalan by Ethacrynic Acid and Hyperthermia in Drug-Sensitive and Multidrug-Resistant Chinese Hamster Ovary Cells. Radiat. Res. 156, 272–282 (2001).The ability of physical and pharmacological modulators to increase the cytotoxicity of melphalan was investigated in Chinese hamster ovary cells using a clonogenic cell survival assay. Hyperthermia has potential for use in cancer treatment, particularly as an adjuvant to chemotherapy or radiotherapy. Ethacrynic acid is a glutathione S-transferase inhibitor and also undergoes conjugation with glutathione. Interactions between hyperthermia (41–43°C), ethacrynic acid and melphalan were evaluated in multidrug-resistant (CHRC5) cells with overexpression of P-glycoprotein (33.69-fold), and in drug-sensitive (AuxB1) cells. GST alpha was expressed at a higher level (3.65-fold) in CHRC5 cells than in sensitive cells, whereas levels of isoforms pi and mu were the same. GST pi was the most highly expressed isoform in the two cell populations. Ethacrynic acid was cytotoxic at elevated temperatures, while it caused little or no cytotoxicity at 37°C. This effect occurred in drug-resistant and drug-sensitive cells, and attributes thermosensitizing properties to ethacrynic acid. Ethacrynic acid (20 μM) alone did not alter the cytotoxicity of melphalan at 37°C. Hyperthermia potentiated drug cytotoxicity in cells, both with and without ethacrynic acid treatment. Ethacrynic acid could be useful in cancer treatment by acting as a thermosensitizer when combined with heat and by enhancing the cytotoxicity of melphalan at elevated temperatures. A major advantage arising from the use of regional hyperthermia is the ability to target drug cytotoxicity to the tumor volume. A useful finding is that ethacrynic acid, heat and/or melphalan are also effective against multidrug-resistant cells with overexpression of P-glycoprotein." @default.
• W2176704368 created "2016-06-24" @default.
• W2176704368 creator A5037297516 @default.
• W2176704368 creator A5076224086 @default.
• W2176704368 date "2001-09-01" @default.
• W2176704368 modified "2023-10-13" @default.
• W2176704368 title "Sensitization to the Cytotoxicity of Melphalan by Ethacrynic Acid and Hyperthermia in Drug-Sensitive and Multidrug-Resistant Chinese Hamster Ovary Cells" @default.
• W2176704368 cites W119080108 @default.
• W2176704368 cites W1493036774 @default.
• W2176704368 cites W1550903142 @default.
• W2176704368 cites W1581414347 @default.
• W2176704368 cites W1660272883 @default.
• W2176704368 cites W1902072415 @default.
• W2176704368 cites W194914142 @default.
• W2176704368 cites W1965632428 @default.
• W2176704368 cites W1965770034 @default.
• W2176704368 cites W1969419384 @default.
• W2176704368 cites W1974302749 @default.
• W2176704368 cites W1981485296 @default.
• W2176704368 cites W1983009519 @default.
• W2176704368 cites W1986369051 @default.
• W2176704368 cites W1992602676 @default.
• W2176704368 cites W2003424401 @default.
• W2176704368 cites W2013677839 @default.
• W2176704368 cites W2022026667 @default.
• W2176704368 cites W2023288226 @default.
• W2176704368 cites W2034031399 @default.
• W2176704368 cites W2039029472 @default.
• W2176704368 cites W2046750894 @default.
• W2176704368 cites W2055752521 @default.
• W2176704368 cites W2057925304 @default.
• W2176704368 cites W2064035407 @default.
• W2176704368 cites W2067493329 @default.
• W2176704368 cites W2068521859 @default.
• W2176704368 cites W2069415301 @default.
• W2176704368 cites W2077238875 @default.
• W2176704368 cites W2077754871 @default.
• W2176704368 cites W2078993996 @default.
• W2176704368 cites W2080328815 @default.
• W2176704368 cites W2090487471 @default.
• W2176704368 cites W2090874882 @default.
• W2176704368 cites W2100837269 @default.
• W2176704368 cites W2105640380 @default.
• W2176704368 cites W2115362310 @default.
• W2176704368 cites W2139026524 @default.
• W2176704368 cites W2144090480 @default.
• W2176704368 cites W2150081412 @default.
• W2176704368 cites W2169295801 @default.
• W2176704368 cites W217594486 @default.
• W2176704368 cites W2199534294 @default.
• W2176704368 cites W237415951 @default.
• W2176704368 cites W4232534952 @default.
• W2176704368 cites W4245957869 @default.
• W2176704368 doi "https://doi.org/10.1667/0033-7587(2001)156[0272:sttcom]2.0.co;2" @default.
• W2176704368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11500136" @default.
• W2176704368 hasPublicationYear "2001" @default.
• W2176704368 type Work @default.
• W2176704368 sameAs 2176704368 @default.
• W2176704368 citedByCount "13" @default.
• W2176704368 countsByYear W21767043682013 @default.
• W2176704368 crossrefType "journal-article" @default.
• W2176704368 hasAuthorship W2176704368A5037297516 @default.
• W2176704368 hasAuthorship W2176704368A5076224086 @default.
• W2176704368 hasConcept C109316439 @default.
• W2176704368 hasConcept C151730666 @default.
• W2176704368 hasConcept C170493617 @default.
• W2176704368 hasConcept C175656101 @default.
• W2176704368 hasConcept C181199279 @default.
• W2176704368 hasConcept C185592680 @default.
• W2176704368 hasConcept C202751555 @default.
• W2176704368 hasConcept C2776694085 @default.
• W2176704368 hasConcept C2778684742 @default.
• W2176704368 hasConcept C2779949491 @default.
• W2176704368 hasConcept C538909803 @default.
• W2176704368 hasConcept C54355233 @default.
• W2176704368 hasConcept C55493867 @default.
• W2176704368 hasConcept C86803240 @default.
• W2176704368 hasConcept C98274493 @default.
• W2176704368 hasConceptScore W2176704368C109316439 @default.
• W2176704368 hasConceptScore W2176704368C151730666 @default.
• W2176704368 hasConceptScore W2176704368C170493617 @default.
• W2176704368 hasConceptScore W2176704368C175656101 @default.
• W2176704368 hasConceptScore W2176704368C181199279 @default.
• W2176704368 hasConceptScore W2176704368C185592680 @default.
• W2176704368 hasConceptScore W2176704368C202751555 @default.
• W2176704368 hasConceptScore W2176704368C2776694085 @default.
• W2176704368 hasConceptScore W2176704368C2778684742 @default.
• W2176704368 hasConceptScore W2176704368C2779949491 @default.
• W2176704368 hasConceptScore W2176704368C538909803 @default.
• W2176704368 hasConceptScore W2176704368C54355233 @default.
• W2176704368 hasConceptScore W2176704368C55493867 @default.
• W2176704368 hasConceptScore W2176704368C86803240 @default.
• W2176704368 hasConceptScore W2176704368C98274493 @default.
• W2176704368 hasIssue "3" @default.
• W2176704368 hasLocation W21767043681 @default.
• W2176704368 hasLocation W21767043682 @default.
• W2176704368 hasOpenAccess W2176704368 @default.
• W2176704368 hasPrimaryLocation W21767043681 @default.

• next