Matches in SemOpenAlex for { <https://semopenalex.org/work/W2176715710> ?p ?o ?g. }
- W2176715710 endingPage "222" @default.
- W2176715710 startingPage "215" @default.
- W2176715710 abstract "Parenteral nutrition constitutes a life-saving therapeutic tool in patients unable to ingest/absorb oral or enteral delivered nutrients. Liver function tests abnormalities are a common therapy-related complication, thus configuring the so-called Parenteral Nutrition Associated Liver Disease (PNALD) or cholestasis (PNAC). Although the damage is frequently mild, and resolves after discontinuation of parenteral nutrition, in some cases it progresses into cirrhotic changes, especially in neonates and infants. We present a literature review focusing on the pathogenetic mechanisms-driven prevention and therapies for the cases where parenteral nutrition cannot be discontinued. Ursodeoxycholic acid has been proposed in patients with cholestatic hepatopathy, but its efficacy needs to be better established. Little evidence is available on efficacy of anti-oxidants, antibiotics, probiotics and anti TNFα. Lipid emulsions based on fish oil with a high content of long-chain polyunsaturated fatty acids ω-3 appear effective both in decreasing intrahepatic inflammation and in improving biliary flow. Most recent promising variations such as soybean/MCT/olive/fish oil emulsion [third generation lipid emulsion (SMOFlipid)] are under investigation. In conclusion, we remark the emergence of a number of novel pathomechanisms underlying the severe liver impairment damage (PNALD and PNAC) in patients treated with parenteral nutrition. Only few traditional and innovative therapeutic strategies have hitherto been shown promising." @default.
- W2176715710 created "2016-06-24" @default.
- W2176715710 creator A5014320281 @default.
- W2176715710 creator A5031935586 @default.
- W2176715710 creator A5044494260 @default.
- W2176715710 creator A5067251291 @default.
- W2176715710 creator A5076854299 @default.
- W2176715710 creator A5079292439 @default.
- W2176715710 date "2016-03-01" @default.
- W2176715710 modified "2023-10-18" @default.
- W2176715710 title "Pediatric parenteral nutrition-associated liver disease and cholestasis: Novel advances in pathomechanisms-based prevention and treatment" @default.
- W2176715710 cites W1556411146 @default.
- W2176715710 cites W1908456340 @default.
- W2176715710 cites W1951454065 @default.
- W2176715710 cites W1963917835 @default.
- W2176715710 cites W1968213691 @default.
- W2176715710 cites W1969935107 @default.
- W2176715710 cites W1972476479 @default.
- W2176715710 cites W1972544609 @default.
- W2176715710 cites W1976983136 @default.
- W2176715710 cites W1984713827 @default.
- W2176715710 cites W1988046322 @default.
- W2176715710 cites W1992621882 @default.
- W2176715710 cites W1992708381 @default.
- W2176715710 cites W1997805777 @default.
- W2176715710 cites W2004736619 @default.
- W2176715710 cites W2005170893 @default.
- W2176715710 cites W2005895469 @default.
- W2176715710 cites W2008176747 @default.
- W2176715710 cites W2008560952 @default.
- W2176715710 cites W2018878497 @default.
- W2176715710 cites W2021050483 @default.
- W2176715710 cites W2022872926 @default.
- W2176715710 cites W2023902430 @default.
- W2176715710 cites W2025782591 @default.
- W2176715710 cites W2025923811 @default.
- W2176715710 cites W2027454153 @default.
- W2176715710 cites W2027544231 @default.
- W2176715710 cites W2032227039 @default.
- W2176715710 cites W2035906727 @default.
- W2176715710 cites W2036086545 @default.
- W2176715710 cites W2036508081 @default.
- W2176715710 cites W2040159748 @default.
- W2176715710 cites W2045852911 @default.
- W2176715710 cites W2047863813 @default.
- W2176715710 cites W2055089766 @default.
- W2176715710 cites W2056512248 @default.
- W2176715710 cites W2058522772 @default.
- W2176715710 cites W2058958528 @default.
- W2176715710 cites W2062141358 @default.
- W2176715710 cites W2062294021 @default.
- W2176715710 cites W2063895612 @default.
- W2176715710 cites W2064467208 @default.
- W2176715710 cites W2066163388 @default.
- W2176715710 cites W2066545864 @default.
- W2176715710 cites W2067806112 @default.
- W2176715710 cites W2067809319 @default.
- W2176715710 cites W2070369077 @default.
- W2176715710 cites W2071464172 @default.
- W2176715710 cites W2074556350 @default.
- W2176715710 cites W2076385022 @default.
- W2176715710 cites W2077501432 @default.
- W2176715710 cites W2077678294 @default.
- W2176715710 cites W2078348828 @default.
- W2176715710 cites W2079417273 @default.
- W2176715710 cites W2083617346 @default.
- W2176715710 cites W2084404442 @default.
- W2176715710 cites W2084700748 @default.
- W2176715710 cites W2085347494 @default.
- W2176715710 cites W2085978613 @default.
- W2176715710 cites W2086171302 @default.
- W2176715710 cites W2087139620 @default.
- W2176715710 cites W2087228124 @default.
- W2176715710 cites W2090728558 @default.
- W2176715710 cites W2091428788 @default.
- W2176715710 cites W2095063281 @default.
- W2176715710 cites W2098919774 @default.
- W2176715710 cites W2102395351 @default.
- W2176715710 cites W2104514985 @default.
- W2176715710 cites W2106454717 @default.
- W2176715710 cites W2109979874 @default.
- W2176715710 cites W2120564666 @default.
- W2176715710 cites W2123189153 @default.
- W2176715710 cites W2124777376 @default.
- W2176715710 cites W2127306171 @default.
- W2176715710 cites W2127504862 @default.
- W2176715710 cites W2128360784 @default.
- W2176715710 cites W2133886842 @default.
- W2176715710 cites W2139729174 @default.
- W2176715710 cites W2144477926 @default.
- W2176715710 cites W2149336536 @default.
- W2176715710 cites W2149487318 @default.
- W2176715710 cites W2157631112 @default.
- W2176715710 cites W2158105321 @default.
- W2176715710 cites W2170356889 @default.
- W2176715710 cites W2171505733 @default.
- W2176715710 cites W2326477103 @default.
- W2176715710 cites W2416247160 @default.