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W2176774871 abstract "Dipeptidyl peptidase IV (DPP4) is a multifunctional type II transmembrane serine peptidase which regulates various physiological processes, most notably plasma glucose homeostasis by cleaving peptide hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Inhibition of DPP4 is a potentially valuable therapy for type 2 diabetes. Synthesis and structure–activity relationships of a series of substituted diprolyl nitriles are described, leading to the identification of compound 1 with a measured DPP4 Ki of 3.6 nM." @default.
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W2176774871 date "2005-09-01" @default.
W2176774871 modified "2023-10-17" @default.
W2176774871 title "Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors" @default.
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W2176774871 doi "https://doi.org/10.1016/j.bmcl.2005.06.043" @default.
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