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- W2176803657 abstract "Genetically encoded voltage indicators (GEVIs) are a promising technology for fluorescence readout of millisecond-scale neuronal dynamics. Previous GEVIs had insufficient signaling speed and dynamic range to resolve action potentials in live animals. We coupled fast voltage-sensing domains from a rhodopsin protein to bright fluorophores through resonance energy transfer. The resulting GEVIs are sufficiently bright and fast to report neuronal action potentials and membrane voltage dynamics in awake mice and flies, resolving fast spike trains with 0.2-millisecond timing precision at spike detection error rates orders of magnitude better than previous GEVIs. In vivo imaging revealed sensory-evoked responses, including somatic spiking, dendritic dynamics, and intracellular voltage propagation. These results empower in vivo optical studies of neuronal electrophysiology and coding and motivate further advancements in high-speed microscopy." @default.
- W2176803657 created "2016-06-24" @default.
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- W2176803657 date "2015-11-19" @default.
- W2176803657 modified "2023-10-17" @default.
- W2176803657 title "High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor" @default.
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- W2176803657 doi "https://doi.org/10.1126/science.aab0810" @default.
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