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- W2176935167 abstract "Abstract Vujaskovic, Z., Feng, Q. F., Rabbani, Z. N., Anscher, M. S., Samulski, T. V. and Brizel, D. M. Radioprotection of Lungs by Amifostine is Associated with Reduction in Profibrogenic Cytokine Activity. Radiat. Res. 157, 656–660 (2002). Radiation-induced pulmonary toxicity causes significant morbidity and mortality in patients irradiated for lung cancer, breast cancer, lymphoma or thymoma. Amifostine is an important drug in the emerging field of cytoprotection. Recent advances in our understanding of the mechanism of radiation-induced injury at the molecular and cellular levels have stimulated interest in the development of effective radioprotective strategies. Accumulation of macrophages with associated production of reactive oxygen species (ROS) and production and activation of cytokines is a key process involved in the pathophysiology of radiation injury in the lung. The purpose of this study was to determine whether the mechanism of radioprotection by amifostine includes reduction in both macroph..." @default.
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- W2176935167 date "2001-11-01" @default.
- W2176935167 modified "2023-09-26" @default.
- W2176935167 title "Radioprotection of lungs by amifostine is associated with reduction in pro-fibrogenic cytokine activity" @default.
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- W2176935167 doi "https://doi.org/10.1016/s0360-3016(01)01989-7" @default.
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