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- W2176935320 abstract "We report a collaborative study of 11 patients with upbeat nystagmus in the primary position of gaze. In most cases the nystagmus behaved in accordance with Alexander's Law; in 3 patients convergence enhanced the nystagmus. Lateral gaze was without effect in 7 instances. Static tilt to prone and supine positions altered the characteristics of the nystagmus in 7 patients. The effects were variable and, in one case, there was reversal of the direction of the nystagmus to downbeating. There was pathological or radiological confirmation of lesions in the pontomedullary junction (2 cases) and the pontomesencephalic junction (2 cases). The findings support previous reports that primary position upbeat nystagmus occurs predominately with intra-axial brainstem lesions. There is one report of its occurrence with an intrinsic cerebellar lesion. Modification of the amplitude of upbeat nystagmus by tilt of the head with respect to gravity in the majority of patients implies an otolith-related component in the genesis of the nystagmus." @default.
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- W2176935320 date "1983-01-01" @default.
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- W2176935320 title "PRIMARY POSITION UPBEATING NYSTAGMUS" @default.
- W2176935320 doi "https://doi.org/10.1093/brain/106.4.949" @default.
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