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- W2176985108 abstract "Chemical investigation of the whole plants of Salvia substolonifera E.Peter yielded seven germacrane sesquiterpenoids, substolides A–G (1–7), an ethoxylated artifact (8), and two known analogues, 6β-tigloyloxyglechomafuran (9) and castanin F (10). Four germacrane 8-acetylation derivatives (1a–4a) were obtained by chemical transformation. Their structures and relative or absolute configurations were elucidated by intensive spectroscopic methods, and single-crystal X-ray diffraction analysis. Compounds 1a–4a, and 5–10 were evaluated for their in vitro anti-angiogenic effects. Compounds 7 and 9 significantly inhibited VEGF-induced human umbilical vein endothelial cell (HUVEC) proliferation in vitro, with IC50 values of 16.15 ± 0.19, and 4.03 ± 0.26 μM, respectively. The structure activity relationship of these compounds is discussed." @default.
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- W2176985108 date "2015-12-01" @default.
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- W2176985108 title "Substolides A–G, germacrane sesquiterpenoids from Salvia substolonifera" @default.
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- W2176985108 doi "https://doi.org/10.1016/j.phytochem.2015.09.013" @default.
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