Matches in SemOpenAlex for { <https://semopenalex.org/work/W2177087922> ?p ?o ?g. }
- W2177087922 endingPage "1266" @default.
- W2177087922 startingPage "1253" @default.
- W2177087922 abstract "Here we identify duplicated genes in five mammalian genomes and classify these duplicates based on the mechanisms by which they were generated. Retrotransposition accounts for at least half of all predicted duplicate genes in these genomes, with tandem and interspersed DNA-mediated duplicates comprising the other half. Estimation of the evolutionary rates in each class revealed greater rate asymmetry between retrotransposed and interspersed DNA duplicate pairs than between tandem duplicates, suggesting that retrotransposed and interspersed DNA duplicates are diverging more quickly. In an attempt to understand the basis of this asymmetry, we identified disruption of flanking DNA as an indicator of new duplicate fate-loss of local synteny accelerates the asymmetry of divergence of interspersed DNA duplicates. We also show that intact retrogenes are enriched in intergenic regions and indel purified regions of the human genome. Moreover, intact retrogenes closest to annotated genes show the greatest levels of purifying selective pressure. Together, these findings suggest that the differential evolution of duplicate genes may be significantly influenced by changes in local genome architecture." @default.
- W2177087922 created "2016-06-24" @default.
- W2177087922 creator A5021614960 @default.
- W2177087922 creator A5049684557 @default.
- W2177087922 creator A5057578195 @default.
- W2177087922 creator A5083063968 @default.
- W2177087922 date "2009-09-01" @default.
- W2177087922 modified "2023-10-10" @default.
- W2177087922 title "Duplication Mechanism and Disruptions in Flanking Regions Determine the Fate of Mammalian Gene Duplicates" @default.
- W2177087922 cites W1519266993 @default.
- W2177087922 cites W1546563018 @default.
- W2177087922 cites W1641544182 @default.
- W2177087922 cites W1944771638 @default.
- W2177087922 cites W1963590211 @default.
- W2177087922 cites W1968002146 @default.
- W2177087922 cites W1969865366 @default.
- W2177087922 cites W1971074826 @default.
- W2177087922 cites W1972429283 @default.
- W2177087922 cites W1979076392 @default.
- W2177087922 cites W1992297402 @default.
- W2177087922 cites W1993237572 @default.
- W2177087922 cites W2007215714 @default.
- W2177087922 cites W2008646367 @default.
- W2177087922 cites W2013798014 @default.
- W2177087922 cites W2021804487 @default.
- W2177087922 cites W2030895290 @default.
- W2177087922 cites W2032510252 @default.
- W2177087922 cites W2035733413 @default.
- W2177087922 cites W2040058302 @default.
- W2177087922 cites W2041624900 @default.
- W2177087922 cites W2042661483 @default.
- W2177087922 cites W2043527294 @default.
- W2177087922 cites W2047405437 @default.
- W2177087922 cites W2055821541 @default.
- W2177087922 cites W2056182546 @default.
- W2177087922 cites W2061151633 @default.
- W2177087922 cites W2062237303 @default.
- W2177087922 cites W2065172786 @default.
- W2177087922 cites W2083488851 @default.
- W2177087922 cites W2095321122 @default.
- W2177087922 cites W2101868204 @default.
- W2177087922 cites W2102881062 @default.
- W2177087922 cites W2103087497 @default.
- W2177087922 cites W2106882534 @default.
- W2177087922 cites W2107427111 @default.
- W2177087922 cites W2110973918 @default.
- W2177087922 cites W2111229238 @default.
- W2177087922 cites W2113275510 @default.
- W2177087922 cites W2113394593 @default.
- W2177087922 cites W2118910836 @default.
- W2177087922 cites W2122310307 @default.
- W2177087922 cites W2122598328 @default.
- W2177087922 cites W2123846230 @default.
- W2177087922 cites W2124166542 @default.
- W2177087922 cites W2127143129 @default.
- W2177087922 cites W2128186498 @default.
- W2177087922 cites W2131351884 @default.
- W2177087922 cites W2132174189 @default.
- W2177087922 cites W2133514124 @default.
- W2177087922 cites W2135224090 @default.
- W2177087922 cites W2137845412 @default.
- W2177087922 cites W2138022567 @default.
- W2177087922 cites W2138178197 @default.
- W2177087922 cites W2138731801 @default.
- W2177087922 cites W2141828080 @default.
- W2177087922 cites W2146443354 @default.
- W2177087922 cites W2148105436 @default.
- W2177087922 cites W2152075687 @default.
- W2177087922 cites W2160364329 @default.
- W2177087922 cites W2170772311 @default.
- W2177087922 cites W4210580032 @default.
- W2177087922 doi "https://doi.org/10.1089/cmb.2009.0074" @default.
- W2177087922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19772436" @default.
- W2177087922 hasPublicationYear "2009" @default.
- W2177087922 type Work @default.
- W2177087922 sameAs 2177087922 @default.
- W2177087922 citedByCount "23" @default.
- W2177087922 countsByYear W21770879222012 @default.
- W2177087922 countsByYear W21770879222013 @default.
- W2177087922 countsByYear W21770879222014 @default.
- W2177087922 countsByYear W21770879222015 @default.
- W2177087922 countsByYear W21770879222016 @default.
- W2177087922 countsByYear W21770879222017 @default.
- W2177087922 countsByYear W21770879222019 @default.
- W2177087922 countsByYear W21770879222020 @default.
- W2177087922 countsByYear W21770879222021 @default.
- W2177087922 crossrefType "journal-article" @default.
- W2177087922 hasAuthorship W2177087922A5021614960 @default.
- W2177087922 hasAuthorship W2177087922A5049684557 @default.
- W2177087922 hasAuthorship W2177087922A5057578195 @default.
- W2177087922 hasAuthorship W2177087922A5083063968 @default.
- W2177087922 hasConcept C104317684 @default.
- W2177087922 hasConcept C119054055 @default.
- W2177087922 hasConcept C135763542 @default.
- W2177087922 hasConcept C141231307 @default.
- W2177087922 hasConcept C153209595 @default.
- W2177087922 hasConcept C174600577 @default.
- W2177087922 hasConcept C195139083 @default.