Matches in SemOpenAlex for { <https://semopenalex.org/work/W2177095360> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2177095360 endingPage "966" @default.
- W2177095360 startingPage "966" @default.
- W2177095360 abstract "<p class=Abstract>The present study was performed to investigate the effect of 2-fluorobenzaldehyde retinoic acid conjugate on activation of STAT3 pathway in human glioma cells. The results revealed that the compound exhibited inhibitory effect on the activation of STAT3 induced constitutively and by interleukin-6. The inhibitory effect on STAT3 activation was found to be concentration- and time-dependent. In U373 glioma cells, 2-fluorobenzaldehyde retinoic acid conjugate treatment caused a significant enhancement in the expression of proapoptotic proteins like Bax and Bak. Its treatment inhibited the expression of genes including, cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor (VEGF) in U373 glioma cells. Furthermore, the conjugate inhibited proliferation, induced apoptosis and caused accumulation of cells in G1-G0 phase of cell cycle. Thus, 2-fluorobenzaldehyde retinoic acid conjugate acts as a potent inhibitor of STAT3 activation that can be promising importance for the prevention and treatment of gliomas.</p><p> </p>" @default.
- W2177095360 created "2016-06-24" @default.
- W2177095360 creator A5003487083 @default.
- W2177095360 creator A5006219539 @default.
- W2177095360 creator A5016416963 @default.
- W2177095360 creator A5037182113 @default.
- W2177095360 creator A5045883195 @default.
- W2177095360 creator A5082526312 @default.
- W2177095360 date "2015-11-22" @default.
- W2177095360 modified "2023-09-26" @default.
- W2177095360 title "Inhibition of cell proliferation by 2-fluorobenzaldehyde retinoic acid conjugate through suppression of STAT3 activation in human glioma cells" @default.
- W2177095360 cites W1917630072 @default.
- W2177095360 cites W1980480652 @default.
- W2177095360 cites W1986864654 @default.
- W2177095360 cites W2006036234 @default.
- W2177095360 cites W2012583627 @default.
- W2177095360 cites W2029312116 @default.
- W2177095360 cites W2032305679 @default.
- W2177095360 cites W2062084642 @default.
- W2177095360 cites W2086715846 @default.
- W2177095360 cites W2100694891 @default.
- W2177095360 cites W2118310862 @default.
- W2177095360 cites W2140088548 @default.
- W2177095360 cites W2158610635 @default.
- W2177095360 cites W2159730182 @default.
- W2177095360 cites W2164857934 @default.
- W2177095360 cites W2166049962 @default.
- W2177095360 cites W2394538632 @default.
- W2177095360 cites W2402530137 @default.
- W2177095360 cites W29766578 @default.
- W2177095360 doi "https://doi.org/10.3329/bjp.v10i4.24165" @default.
- W2177095360 hasPublicationYear "2015" @default.
- W2177095360 type Work @default.
- W2177095360 sameAs 2177095360 @default.
- W2177095360 citedByCount "0" @default.
- W2177095360 crossrefType "journal-article" @default.
- W2177095360 hasAuthorship W2177095360A5003487083 @default.
- W2177095360 hasAuthorship W2177095360A5006219539 @default.
- W2177095360 hasAuthorship W2177095360A5016416963 @default.
- W2177095360 hasAuthorship W2177095360A5037182113 @default.
- W2177095360 hasAuthorship W2177095360A5045883195 @default.
- W2177095360 hasAuthorship W2177095360A5082526312 @default.
- W2177095360 hasBestOaLocation W21770953601 @default.
- W2177095360 hasConcept C104317684 @default.
- W2177095360 hasConcept C134306372 @default.
- W2177095360 hasConcept C153911025 @default.
- W2177095360 hasConcept C185592680 @default.
- W2177095360 hasConcept C190283241 @default.
- W2177095360 hasConcept C197336794 @default.
- W2177095360 hasConcept C199835354 @default.
- W2177095360 hasConcept C2775975398 @default.
- W2177095360 hasConcept C2778227246 @default.
- W2177095360 hasConcept C2778923194 @default.
- W2177095360 hasConcept C2781121885 @default.
- W2177095360 hasConcept C29537977 @default.
- W2177095360 hasConcept C33923547 @default.
- W2177095360 hasConcept C502942594 @default.
- W2177095360 hasConcept C55493867 @default.
- W2177095360 hasConcept C62112901 @default.
- W2177095360 hasConcept C86803240 @default.
- W2177095360 hasConceptScore W2177095360C104317684 @default.
- W2177095360 hasConceptScore W2177095360C134306372 @default.
- W2177095360 hasConceptScore W2177095360C153911025 @default.
- W2177095360 hasConceptScore W2177095360C185592680 @default.
- W2177095360 hasConceptScore W2177095360C190283241 @default.
- W2177095360 hasConceptScore W2177095360C197336794 @default.
- W2177095360 hasConceptScore W2177095360C199835354 @default.
- W2177095360 hasConceptScore W2177095360C2775975398 @default.
- W2177095360 hasConceptScore W2177095360C2778227246 @default.
- W2177095360 hasConceptScore W2177095360C2778923194 @default.
- W2177095360 hasConceptScore W2177095360C2781121885 @default.
- W2177095360 hasConceptScore W2177095360C29537977 @default.
- W2177095360 hasConceptScore W2177095360C33923547 @default.
- W2177095360 hasConceptScore W2177095360C502942594 @default.
- W2177095360 hasConceptScore W2177095360C55493867 @default.
- W2177095360 hasConceptScore W2177095360C62112901 @default.
- W2177095360 hasConceptScore W2177095360C86803240 @default.
- W2177095360 hasIssue "4" @default.
- W2177095360 hasLocation W21770953601 @default.
- W2177095360 hasOpenAccess W2177095360 @default.
- W2177095360 hasPrimaryLocation W21770953601 @default.
- W2177095360 hasRelatedWork W2185175380 @default.
- W2177095360 hasRelatedWork W2374067319 @default.
- W2177095360 hasRelatedWork W2383691845 @default.
- W2177095360 hasRelatedWork W2530512275 @default.
- W2177095360 hasRelatedWork W2626027566 @default.
- W2177095360 hasRelatedWork W2762525387 @default.
- W2177095360 hasRelatedWork W2963313573 @default.
- W2177095360 hasRelatedWork W3031579642 @default.
- W2177095360 hasRelatedWork W3032052330 @default.
- W2177095360 hasRelatedWork W3136311700 @default.
- W2177095360 hasVolume "10" @default.
- W2177095360 isParatext "false" @default.
- W2177095360 isRetracted "false" @default.
- W2177095360 magId "2177095360" @default.
- W2177095360 workType "article" @default.