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- W2177108257 abstract "Mappicine and mappicine ketone are camptothecin analogs of interest as antiviral agents. A novel synthesis of these compounds is described using a Friedlander condensation. The requisite ketone is prepared via a regioselective ortho-directed metallation/alkylation of a trisubstituted pyridine. This is condensed with N-t-butyloxycarbonyl-o-aminobenzaldehyde as a convenient, stable o-aminobenzaldehyde equivalent in the Friedlander condensation." @default.
- W2177108257 created "2016-06-24" @default.
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- W2177108257 date "2004-01-13" @default.
- W2177108257 modified "2023-09-26" @default.
- W2177108257 title "Synthesis of (+/-) Mappicine and Mappicine Ketone." @default.
- W2177108257 cites W2950049224 @default.
- W2177108257 doi "https://doi.org/10.1002/chin.200402202" @default.
- W2177108257 hasPublicationYear "2004" @default.
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