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- W2177228438 abstract "The International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) have recently reported in Nature their analysis of more than 1000 chronic lymphocytic leukemia (CLL) genomes.1, 2 CLL, the most common leukemia in adults of Western countries, is a neoplasia characterized by an abnormal accumulation of B lymphocytes in blood, lymph nodes and bone marrow. This disease has traditionally been classified into two molecular groups according to whether the variable region of immunoglobulin heavy-chain genes of tumor B cells has undergone somatic hypermutation in the germline center (IGHV-mut) or not (IGHV-unmut). The former is associated with a favorable clinical course, whereas the latter represents the most aggressive form of the disease. Clinical heterogeneity and high prevalence are the defining features of CLL, but the driving events responsible for its initiation and development are poorly understood.3, 4 On this basis, ICGC and TCGA projects were set up in 2008 to identify the genetic alterations that trigger this neoplasia." @default.
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- W2177228438 date "2015-11-27" @default.
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- W2177228438 title "Chronic lymphocytic leukemia: looking into the dark side of the genome" @default.
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- W2177228438 doi "https://doi.org/10.1038/cdd.2015.155" @default.
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