FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2177291250> ?p ?o ?g. }

• W2177291250 endingPage "7" @default.
• W2177291250 startingPage "1" @default.
• W2177291250 abstract "The aims of the present work were to study the effects of chronic NO inhibition on liver cirrhosis and to analyze its relationship with liver and kidney damage markers. Two inhibitors of NO synthesis (inducible NO synthase (iNOS) inhibitor, aminoguanidine (AG), and nonselective NOS inhibitor, L-nitroarginine methyl ester (L-NAME)) were administered for 6 weeks to bile duct ligated (BDL) rats 3 days after surgery. The present study showed that BDL was associated with liver injury and renal impairment. BDL increased liver NO content and myeloperoxidase (MPO) activity. This was corroborated by increased oxidative stress, TNF- α , TGF-1 β , and MMP-13 genes overexpression. Although both drugs reduced NO synthesis and TNF- α gene overexpression, only AG improved renal dysfunction and liver damage and reduced liver oxidative stress. However, L-NAME exacerbated liver and renal dysfunction. Both drugs failed to modulate TGF-1 β and MMP-13 genes overexpression. In conclusion, inhibition of NO production by constitutive nitric oxide synthase (cNOS) plays a crucial role in liver injury and renal dysfunction while inhibition of iNOS by AG has beneficial effect. TNF- α is not the main cytokine responsible for liver injury in BDL model. Nitric oxide inhibition did not stop the progression of cholestatic liver damage." @default.
• W2177291250 created "2016-06-24" @default.
• W2177291250 creator A5004499620 @default.
• W2177291250 creator A5008349986 @default.
• W2177291250 creator A5031177028 @default.
• W2177291250 date "2015-01-01" @default.
• W2177291250 modified "2023-09-24" @default.
• W2177291250 title "Can Chronic Nitric Oxide Inhibition Improve Liver and Renal Dysfunction in Bile Duct Ligated Rats?" @default.
• W2177291250 cites W1002512956 @default.
• W2177291250 cites W1589390056 @default.
• W2177291250 cites W1821918060 @default.
• W2177291250 cites W1915653201 @default.
• W2177291250 cites W1939197819 @default.
• W2177291250 cites W1976582993 @default.
• W2177291250 cites W1983310681 @default.
• W2177291250 cites W1991882176 @default.
• W2177291250 cites W2004030501 @default.
• W2177291250 cites W2013748376 @default.
• W2177291250 cites W2029054651 @default.
• W2177291250 cites W2037703936 @default.
• W2177291250 cites W2044168407 @default.
• W2177291250 cites W2049796621 @default.
• W2177291250 cites W2051142023 @default.
• W2177291250 cites W2056192010 @default.
• W2177291250 cites W2056695599 @default.
• W2177291250 cites W2057794192 @default.
• W2177291250 cites W2069397517 @default.
• W2177291250 cites W2088933145 @default.
• W2177291250 cites W2101142782 @default.
• W2177291250 cites W2103154229 @default.
• W2177291250 cites W2148124253 @default.
• W2177291250 cites W2148791706 @default.
• W2177291250 cites W2158272509 @default.
• W2177291250 cites W2160795517 @default.
• W2177291250 cites W2200298303 @default.
• W2177291250 cites W2216952605 @default.
• W2177291250 cites W2263023695 @default.
• W2177291250 cites W2266929960 @default.
• W2177291250 cites W2402002018 @default.
• W2177291250 cites W2403211199 @default.
• W2177291250 cites W2914914099 @default.
• W2177291250 cites W4253015600 @default.
• W2177291250 doi "https://doi.org/10.1155/2015/298792" @default.
• W2177291250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4673328" @default.
• W2177291250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26692194" @default.
• W2177291250 hasPublicationYear "2015" @default.
• W2177291250 type Work @default.
• W2177291250 sameAs 2177291250 @default.
• W2177291250 citedByCount "6" @default.
• W2177291250 countsByYear W21772912502017 @default.
• W2177291250 countsByYear W21772912502018 @default.
• W2177291250 countsByYear W21772912502019 @default.
• W2177291250 countsByYear W21772912502020 @default.
• W2177291250 countsByYear W21772912502021 @default.
• W2177291250 countsByYear W21772912502022 @default.
• W2177291250 crossrefType "journal-article" @default.
• W2177291250 hasAuthorship W2177291250A5004499620 @default.
• W2177291250 hasAuthorship W2177291250A5008349986 @default.
• W2177291250 hasAuthorship W2177291250A5031177028 @default.
• W2177291250 hasBestOaLocation W21772912501 @default.
• W2177291250 hasConcept C126322002 @default.
• W2177291250 hasConcept C134018914 @default.
• W2177291250 hasConcept C2776151105 @default.
• W2177291250 hasConcept C2776637226 @default.
• W2177291250 hasConcept C2777214474 @default.
• W2177291250 hasConcept C2777622882 @default.
• W2177291250 hasConcept C2780091579 @default.
• W2177291250 hasConcept C2780472472 @default.
• W2177291250 hasConcept C519581460 @default.
• W2177291250 hasConcept C71924100 @default.
• W2177291250 hasConcept C98274493 @default.
• W2177291250 hasConceptScore W2177291250C126322002 @default.
• W2177291250 hasConceptScore W2177291250C134018914 @default.
• W2177291250 hasConceptScore W2177291250C2776151105 @default.
• W2177291250 hasConceptScore W2177291250C2776637226 @default.
• W2177291250 hasConceptScore W2177291250C2777214474 @default.
• W2177291250 hasConceptScore W2177291250C2777622882 @default.
• W2177291250 hasConceptScore W2177291250C2780091579 @default.
• W2177291250 hasConceptScore W2177291250C2780472472 @default.
• W2177291250 hasConceptScore W2177291250C519581460 @default.
• W2177291250 hasConceptScore W2177291250C71924100 @default.
• W2177291250 hasConceptScore W2177291250C98274493 @default.
• W2177291250 hasLocation W21772912501 @default.
• W2177291250 hasLocation W21772912502 @default.
• W2177291250 hasLocation W21772912503 @default.
• W2177291250 hasLocation W21772912504 @default.
• W2177291250 hasOpenAccess W2177291250 @default.
• W2177291250 hasPrimaryLocation W21772912501 @default.
• W2177291250 hasRelatedWork W1623258072 @default.
• W2177291250 hasRelatedWork W1972190589 @default.
• W2177291250 hasRelatedWork W2008087125 @default.
• W2177291250 hasRelatedWork W2042033030 @default.
• W2177291250 hasRelatedWork W2044943066 @default.
• W2177291250 hasRelatedWork W2087337247 @default.
• W2177291250 hasRelatedWork W2089295326 @default.
• W2177291250 hasRelatedWork W2093911704 @default.
• W2177291250 hasRelatedWork W2127085070 @default.
• W2177291250 hasRelatedWork W2400445066 @default.

• next